新医学2025，Vol.56Issue(4)：414-419,6.DOI:10.12464/j.issn.0253-9802.2023-0372
基于肠道菌群机制的1型糖尿病防治研究
Research on the prevention and treatment of type 1 diabetes based on the mechanism of gut microbiota
摘要
Abstract
The incidence of type 1 diabetes mellitus(T1DM)is increasing globally,with environmental factors playing a significant role in its onset and progression.Studies have shown that gut microbiota dysbiosis may lead to T1DM through mechanisms such as altering intestinal permeability,modifying the abundance of microbial metabolites,and regulating immune responses.While insulin remains the primary therapeutic means,targeting the gut microbiota has emerged as a promising research focus for T1DM intervention.This article reviews the relationship between gut microbiota and T1DM,discusses the preventive and therapeutic effects of probiotics on T1DM and their underlying mechanisms,aiming to provide new insights for T1DM prevention and treatment research.关键词
1 型糖尿病/肠道菌群/益生菌/预防/治疗Key words
Type 1 diabetes mellitus/Gut microbiota/Probiotics/Prevention/Treatment引用本文复制引用
李莹,徐平,薛萌,梁真,王嘉森..基于肠道菌群机制的1型糖尿病防治研究[J].新医学,2025,56(4):414-419,6.基金项目
国家自然科学基金(82170842) （82170842）
深圳市科技计划项目(KCXFZ20201221173600001) （KCXFZ20201221173600001）
