亚太传统医药2025，Vol.21Issue(4)：39-43,5.DOI:10.11954/ytctyy.202504008
骨碎补总黄酮纳米混悬液制备及其生物利用度研究
Study on the Preparation of Total Flavonoids Nanosuspension of Broken Bone Supplement and its Bioavailability
摘要
Abstract
Objective:The preparation of total flavonoid nano-suspensions of bone distillate using ultrasonic extraction,rotary evaporation,and high-pressure homogenization methods was conducted to investigate its bioavailability in rats.Methods:12 rats were randomly divided into 2 groups,with 6 rats in the bone distillate total flavonoid suspension group and 6 rats in the bone distillate total flavonoid nano-suspension group,with an equal distribution of male and female rats in each group.Bone distillate total flavonoids were extracted using ultrasound-alcohol extraction method,and"nano-crystal"technology was employed to prepare bone distillate total flavonoid nano-suspensions.The rats were adminis-tered orally,and the blood drug concentration-time distribution characteristics of bone distillate total flavonoids in the rats were determined using an enzyme-linked immunosorbent assay(ELISA).Results:After gastric administration of equidose bone distillate total flavonoid suspension and bone distillate total flavonoid nano-suspension(1.2g/kg)to rats,the blood drug concentration-time curves of bone distillate total flavonoids in plasma displayed a bimodal pattern.The bioavailability of bone distillate total flavonoid nano-suspension group was significantly higher than that of the bone distillate total flavonoid suspension group after 24 hours of administration(P＜0.05).The bioavailability of the maxi-mum blood concentration Cmax of bone distillate total flavonoids in the nano-suspension group increased by 3.03 times during the 0-24h period,with a total relative bioavailability of 149.00％compared to the bone distillate total flavonoid suspension group.Conclusion:The bone distillate total flavonoid nano-suspension significantly enhances the oral bio-availability of bone distillate total flavonoids.关键词
骨碎补总黄酮/纳米混悬液/生物利用度Key words
Total Flavonoids of Broken Bone Supplement/Nanosuspension/Bioavailability分类
医药卫生引用本文复制引用
李芳,杨渊,赵安志,李杰康,庞淑文,边泽姿,鲍家成..骨碎补总黄酮纳米混悬液制备及其生物利用度研究[J].亚太传统医药,2025,21(4):39-43,5.基金项目
广西壮族自治区大学生创新创业训练计划项目(S202310601163 （）
202410601041) （）
中国民族医药学会科研项目(2023MY101-22) （2023MY101-22）
