医学信息2025，Vol.38Issue(7)：18-24,7.DOI:10.3969/j.issn.1006-1959.2025.07.003
基于网络药理学探讨黄芩治疗肺癌的有效成分和作用机制
The Effective Components and Mechanism of Radix Scutellariae in the Treatment of Lung Cancer Based on Network Pharmacology
摘要
Abstract
Objective To analyze the potential targets and mechanism of radix scutellariae in the treatment of lung cancer based on network pharmacology.Methods The active components and target genes of radix scutellariae were obtained by TCMSP,and the lung cancer-related genes were obtained by GeneCards and OMIM databases,and the intersection genes of the two were taken.The PPI network diagram of the intersection genes was obtained using the String database,and the GO analysis and KEGG enrichment analysis of the key target genes were performed using the R software clusterProfiler package.Results A total of 36 compounds,341 compound targets and 2487 lung cancer-related target genes were obtained.There were 55 nodes and 8 key nodes in PPI protein interaction network.GO functional enrichment analysis obtained 93 biological processes,and KEGG pathway enrichment analysis obtained 137 signaling pathways.The main active components such as wogonin,baicalein,acacetin and β-sitosterol were obtained.The main core targets included AKT1,IL6,HIF1 A,JUN,CCND1,ESR1,PTGS2,VEGFA,etc.Key signaling pathways mainly include AGE-RAGE,IL-17,apoptosis,small cell lung cancer,p53 and other signaling pathways.Conclusion The main active ingredients in radix scutellariae,such as wogonin,baicalein,acacetin and β-sitosterol,may act on AKT1,IL6,HIF1 A,JUN,CCND1,ESR1,PTGS2,VEGFA and other targets through AGE-RAGE,IL-17,apoptosis,small cell lung cancer,p53 and other signaling pathways,and then play the role of radix scutellariae in anti-lung cancer,showing the characteristics of multi-component,multi-target and multi-pathway.关键词
网络药理学/黄芩/肺癌/活性成分Key words
Network pharmacology/Radix scutellariae/Lung cancer/Active component分类
中医学引用本文复制引用
杨若青,刘艳宏,王琳,胡静池,谭辉..基于网络药理学探讨黄芩治疗肺癌的有效成分和作用机制[J].医学信息,2025,38(7):18-24,7.基金项目
1.重庆市教育委员会科学技术研究计划青年项目资助项目(编号:KJQN202202701) （编号:KJQN202202701）
2.重庆三峡医药高等专科学校校级自然科学项目(编号:2019XZYB16) （编号:2019XZYB16）
