医学信息2025，Vol.38Issue(7)：60-66,104,8.DOI:10.3969/j.issn.1006-1959.2025.07.010
特发性肌炎相关肺间质病与特发性肺纤维化的临床比较
Clinical Comparison Between Idiopathic Myositis-associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis
摘要
Abstract
Objective To compare the clinical characteristics of idiopathic myositis interstitial lung disease(PM/DM-ILD)and idiopathic interstitial pulmonary fibrosis(IPF).Methods A total of 43 patients diagnosed with PM/DM-ILD who were hospitalized in our hospital from October 2018 to October 2021 were selected.According to the results of MDA5 antibody test,they were divided into MDA5-ILD group(n=13)and non-MDA5-ILD group(n=30).In addition,40 patients with IPF who were hospitalized during the same period were selected as IPF group.The general condition,clinical symptoms,laboratory examination,pulmonary function and chest HRCT of the three groups were retrospectively analyzed.Results The course of disease in MDA5-ILD group was shorter than that in non-MDA5-ILD group and IPF group,alanine aminotransferase and GCO scores were higher than those in IPF group,high density lipoprotein was lower than that in IPF group,alanine aminotransferase and GCO scores were higher than those in non-MDA5-ILD group(P<0.016).The positive rate of ARS antibody in non-MDA5-ILD group was higher than that in MDA5-ILD group(P<0.016).The positive rate of muscle enzyme elevation in IPF group was higher than that in MDA5-ILD group(P<0.016).Male patients,age of onset,DLCO%pre reduction,F score and C score in IPF group were higher than those in MDA5-ILD group and non-MDA5-ILD group(P<0.016).The lung function of the three groups showed restrictive ventilation function with diffusion dysfunction.The HRCT classification of the MDA5-ILD group was more common with AIP and OP.The HRCT classification of the non-MDA5-ILD group was more common with NSIP.Conclusion The clinical characteristics of PM/DM-ILD are completely different from those of IPF group.There are differences in clinical characteristics between MDA5-ILD and non-MDA5-ILD.Myositis antibody and HRCT play an important role in the diagnosis and treatment of ILD.关键词
间质性肺疾病/特发性肌炎/特发性肺纤维化/MDA5抗体Key words
Interstitial lung disease/Idiopathic myositis/Idiopathic pulmonary fibrosis/MDA5 antibody分类
临床医学引用本文复制引用
张明,周淑红,张凯,陈英,梁刘娜,张兆翠,潘亮..特发性肌炎相关肺间质病与特发性肺纤维化的临床比较[J].医学信息,2025,38(7):60-66,104,8.基金项目
甘肃省自然科学基金(编号:22JR5RA68) （编号:22JR5RA68）
