摘要
Abstract
Objective To study the application effect of dipherelin and dinogest in patients with ovarian endometriosis(OEM)after laparoscopic surgery.Methods According to the random number table method,60 OEM patients admitted to the Port Hospital of Tianjin from January 2021 to September 2022 were divided into 30 patients in the dinogest group and 30 patients in the dipherelin group.The dipherelin group was treated with dipherelin injection,and the dinogest group was treated with oral dinogest.The pain symptoms[chronic pain grading questionnaire(CPG)],ovarian reserve function[anti-Müllerian hormone(AMH),follicle stimulating hormone(FSH),antral follicle count(AFC)],serum carbohydrate antigen 125(CA125)level,drug side effects(perimenopausal symptoms,vaginal bleeding,sudden bleeding,bone mineral density decreased),recurrence were compared between the two groups.Results Compared with before treatment,the CPG scores of non-menstrual lower abdominal pain,dysmenorrhea and dyspareunia in the two groups after treatment were decreased,and the CPG scores of non-menstrual lower abdominal pain,dysmenorrhea and dyspareunia in the dinogest group after treatment were lower than those in the dipherelin group(P<0.05).Compared with before treatment,the indexes of AMH,FSH and AFC in the two groups decreased after treatment,but the indexes of AMH,FSH and AFC in the dienogest group were higher than those in the dipherelin group after treatment(P<0.05).Compared with before treatment,the level of serum CA125 in the two groups decreased after treatment,and the level of serum CA125 in the dinogest group was lower than that in the diphereline group after treatment(P<0.05).The incidence of drug side effects and the recurrence rate after 12 months of treatment in the dienogest group were lower than those in the dipherelin group(P<0.05).Conclusion Diphereline and dinogest both have exact effects after OEM laparoscopic surgery,which can relieve pain symptoms,improve ovarian reserve function,and down-regulate serum CA-125 level.However,the latter has better effect,less risk of recurrence,and relatively higher drug safety.关键词
卵巢型子宫内膜异位症/达菲林/地诺孕素/腹腔镜手术/卵巢储备功能Key words
Ovarian endometriosis/Diphereline/Dinogest/Laparoscopic surgery/Ovarian reserve function分类
医药卫生
