医学信息2025，Vol.38Issue(7)：187-192,6.DOI:10.3969/j.issn.1006-1959.2025.07.038
miRNAs在卵巢癌发病机制和治疗耐药中的作用
Role of miRNAs in the Pathogenesis and Treatment Resistance of Ovarian Cancer
摘要
Abstract
Ovarian cancer(OC)is the main cause of death in gynecological cancer.OC is asymptomatic in the early stage and has no specific symptoms in the late stage.Therefore,more than 75%of OC cases are diagnosed as advanced stage.It has been reported that a variety of epigenetic factors such as miRNAs can affect OC,including initiation,progression,angiogenesis,and resistance to treatment.MiRNAs can regulate the expression of multiple genes involved in the pathogenesis of OC.This effect is attributed to the role of miRNA in initiation,proliferation,and metastasis.MiRNAs also affect key OC-related mechanism pathways,such as JAK/STAT axis,NF-κB signaling,MAPK signaling pathway,PI3K/AKT signaling pathway.In addition to the pathogenesis,miRNAs may also affect the response of OC to chemotherapy and the biological process of tumor cells.Based on this,this paper intends to clarify the relationship between miRNAs and OC,focusing on the effect of miRNAs on OC signaling pathway.关键词
耐药性/卵巢癌/发病机制/微小核糖核酸Key words
Drug resistance/Ovarian cancer/Pathogenesis/MicroRNA分类
医药卫生引用本文复制引用
王芳,杨永秀..miRNAs在卵巢癌发病机制和治疗耐药中的作用[J].医学信息,2025,38(7):187-192,6.基金项目
兰州大学医学教育创新发展项目(编号:lzuyx-cx-2022-200) （编号:lzuyx-cx-2022-200）
