医学信息2025，Vol.38Issue(8)：65-69,5.DOI:10.3969/j.issn.1006-1959.2025.08.013
清热安胎膏改善大鼠妊娠期龈炎及对SOD、CAT活性的影响
Effect of Qingre Antai Paste on the Improvement of Gingivitis and the Activity of SOD and CAT in Rats During Pregnancy
摘要
Abstract
Objective To observe the effect of Qingre Antai paste on the activity of superoxide dismutase(SOD)and catalase(CAT)in rats with gingivitis during pregnancy.Methods A total of 24 9-week-old SPF SD female rats and 12 male rats were purchased from Beijing Charles River Company.Female rats were randomly divided into four experimental groups:blank control group,model group,positive drug control group and traditional Chinese medicine group,with 6 rats in each group.After adaptive feeding,experimental gingivitis was constructed.After 7 days,they were conceived in a cage,and after 3 days of conception,they were grouped.The gingival state of rats in each group after modeling and group treatment was recorded.Blank control group:without any treatment,conventional conception;model group:pregnancy after experimental gingivitis was constructed;positive drug control group:experimental gingivitis was constructed,and iodine glycerin was given at the gingival sulcus after conception;traditional Chinese medicine group:experimental gingivitis was constructed,and Qingre Antai paste was filled in the gingival sulcus after conception.After grouping treatment,the gingival tissue was cut,and the activity levels of SOD and CAT in the gingival tissue of the experimental rats were determined by enzyme-linked immunosorbent assay(ELISA).Results After modeling,the gums of the lower incisors of the rats showed obvious congestion,redness and swelling.The degree of gingival swelling after treatment in each group of rats during pregnancy:model group＞traditional Chinese medicine group≥positive drug control group＞blank control group.Compared with the blank control group,the activity of SOD and CAT in the model group,the positive drug control group and the traditional Chinese medicine group decreased(P＜0.05).The activities of SOD and CAT in the traditional Chinese medicine group were higher than those in the model group(P＜0.05).Conclusion Qingre Antai paste can effectively improve the activity of SOD and CAT in rats with gingivitis during pregnancy,improve oxidative stress,and reduce the swelling and damage of gingival tissue.It is expected to become a new method for the treatment of gingivitis during pregnancy.关键词
妊娠期龈炎/清热安胎膏/氧化应激Key words
Pregnancy gingivitis/Qingre Antai paste/Oxidative stress分类
中医学引用本文复制引用
陆静宇,陈世娟,王楚睿,康静..清热安胎膏改善大鼠妊娠期龈炎及对SOD、CAT活性的影响[J].医学信息,2025,38(8):65-69,5.基金项目
湖南省自然科学基金项目(编号:211142196052) （编号:211142196052）
