摘要
Abstract
Objective To investigate the effect of edaravone and dextrorphan combined with alteplase on cerebral hemodynamic status,neurological function and prognosis in patients with acute ischemic stroke.Methods A total of 60 patients with acute ischemic stroke admitted to the Department of Neurology,Ji'an County People's Hospital from January 2021 to December 2023 were selected as the research objects.According to the random number table method,they were divided into control group and study group,with 30 patients in each group.The control group was treated with intravenous thrombolysis with alteplase,and the study group was treated with edaravone and dextrorphan injection concentrated solution on the basis of the control group.The treatment efficiency,neurological function(NIHSS score,CSS score),cerebral hemodynamic status(pulsatility index,resistance index,mean blood flow velocity),inflammatory factor levels[tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-2(IL-2)]and vascular recanalization rate were compared between the two groups.Results The effective rate of treatment in the study group was higher than that in the control group(P＜0.05).After treatment,the neurological function of the study group was better than that of the control group(P＜0.05).The pulsatility index and resistance index of the study group were lower than those of the control group,while the average blood flow velocity was higher than that of the control group(P＜0.05).The levels of inflammatory factors in the study group were lower than those in the control group,and the vascular recanalization rate was higher than that in the control group(P＜0.05).Conclusion Edaravone and dextrose combined with alteplase is effective in the treatment of patients with acute ischemic stroke,which can improve their neurological function and cerebral hemodynamic status,reduce the inflammatory response of patients,and improve the vascular recanalization rate of patients.It has excellent clinical value.关键词
依达拉奉右莰醇/阿替普酶/急性缺血性脑卒/脑血流动力学状态/神经功能/预后Key words
Edaravone and dextrocamphenol/Alteplase/Acute ischemic cerebral infarction/Cerebral hemodynamic state/Nerve function/Prognosis分类
医药卫生
