医学信息2025，Vol.38Issue(8)：118-122,5.DOI:10.3969/j.issn.1006-1959.2025.08.024
利水保肝巴布剂对肝腹水的药效评价
Pharmacodynamic Evaluation of Lishui Baogan Cataplasm on Hepatic Ascites
摘要
Abstract
Objective To investigate the effect of Lishui Baogan cataplasm for the treatment of hepatic ascites.Methods The mouse model of hepatic ascites was established by H22 tumor cells.One day after modeling,the blank group and the model group were given blank matrix paste,the positive drug group was given furosemide suspension[6 mg/(kg·d)],and the low,medium and high dose groups of cataplasm were given crude drug doses of 0.15 g/(cm2·d),0.30 g/(cm2·d),0.60 g/(cm2·d),respectively,the administration area was 4 cm2,once a day for 10 days.The body weight of mice was weighed,the abdominal circumference was measured,the number of deaths in mice was counted,and the urine volume and ascites volume of mice were recorded.The contents of serum albumin(ALB),total protein(TP),aspartate aminotransferase(AST)and alanine aminotransferase(ALT)in mice were detected by ELISA,and the pathological changes of liver tissue in mice were observed by HE staining.Results The mice in the black group were in good health with normal weight and abdominal circumference,and no signs of death.Compared with the black group,the weight and abdominal circumference of mice in the low,medium and high dose groups of cataplasm significantly increased(P＜0.05).Compared with the blank group,the mortality rate of the model group was significantly increased,reaching 54.54%.Compared with the blank group,the average urine volume of mice in the model group decreased(P＜0.01).Compared with the model group,the urine volume of the positive drug group and the low,medium and high dose groups of cataplasm increased,and the ascites of the positive drug group and the low,medium and high dose groups of cataplasm decreased to varying degrees,among which the ascites of the medium dose group decreased significantly(P＜0.05).The serum AST and ALT levels of mice in each dose group of cataplasm were reduced,while the TP level was increased(P＜0.05).HE staining sections of liver tissue showed that compared with the model group,liver injury in each dose group of cataplasm was alleviated to varying degrees.Conclusion Lishui Baogan cataplasm has obvious effect on ascites and liver protection.关键词
巴布剂/肝腹水/药效评价Key words
Cataplasm/Hepatic ascites/Pharmacodynamic evaluation分类
医药卫生引用本文复制引用
丁艳霞,王佳,司玉环,杜雅情,余聪睿,刘晨,魏倩囡..利水保肝巴布剂对肝腹水的药效评价[J].医学信息,2025,38(8):118-122,5.基金项目
1.国家级大学生创新创业训练计划(编号:202310475017) （编号:202310475017）
2.河南大学大学生创新创业训练计划(编号:校发[2022]137号) （编号:校发[2022]137号）
