医学信息2025，Vol.38Issue(8)：123-126,4.DOI:10.3969/j.issn.1006-1959.2025.08.025
麝香通心滴丸预防心导管术后造影剂所致急性肾损伤的临床研究
Clinical Study of Shexiang Tongxin Dropping Pills on Prevention of Contrast-induced Acute Kidney Injury After Cardiac Catheterization
摘要
Abstract
Objective To study the effect of Shexiang Tongxin dropping pills on the prevention of contrast-induced acute kidney injury(CI-AKI)after cardiac catheterization.Methods A total of 402 patients who underwent coronary angiography or percutaneous coronary intervention in our hospital from January 2022 to November 2023 were selected as the research objects.They were divided into control group and experimental group by random number table method,with 201 patients in each group.The experimental group began to take Shexiang Tongxin dropping pills orally on the day of admission,while the control group did not take Shexiang Tongxin dropping pills orally.The incidence of acute kidney injury,renal function index,inflammatory factor index,renal artery resistance index(RRI)and incidence of adverse cardiac events were compared between the two groups.Results The incidence of CI-AKI in the experimental group(3.48%)was lower than that in the control group(16.42%)(P＜0.05).The serum creatinine(SCr)and urea nitrogen(BUN)in the two groups were higher than those before operation,and the glomerular filtration rate(eGFR)was lower than that before operation,but the SCr and BUN in the experimental group were lower than those in the control group,and the eGFR was higher than that in the control group(P＜0.05).The levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the two groups were higher than those before operation,but those in the experimental group were lower than the control group(P＜0.05).The RRI of the two groups was higher than that before operation,but that of the experimental group was lower than that of the control group(P＜0.05).After 3 months of follow-up,there was no significant difference in the incidence of adverse cardiac events between the experimental group(1.99%)and the control group(2.99%)(P＞0.05).Conclusion Shexiang Tongxin dropping pills is effective in preventing CI-AKI caused by contrast agent after cardiac catheterization,which can inhibit inflammatory reaction,reduce renal injury and the incidence of CI-AKI.关键词
麝香通心滴丸/心导管术/造影剂/CI-AKIKey words
Shexiang Tongxin dropping pills/Cardiac catheterization/Contrast agent/CI-AKI分类
医药卫生引用本文复制引用
谢礼鑫,陈婷,袁永强..麝香通心滴丸预防心导管术后造影剂所致急性肾损伤的临床研究[J].医学信息,2025,38(8):123-126,4.基金项目
江西省中医药管理局科技计划项目(编号:SZYYB20232192) （编号:SZYYB20232192）
