应用化学2025，Vol.42Issue(3)：313-320,8.DOI:10.19894/j.issn.1000-0518.240321
共价有机框架修饰硅胶复合材料在高效液相色谱中的研究进展
Research Progress of Covalent Organic Framework Modified Silica Gel Composites in High Performance Liquid Chromatography
摘要
Abstract
Covalent organic framework(COFs)has the advantages of high stability,easy modification and structural designability,and is regarded as a powerful choice for new stationary phase of high performance liquid chromatography.Although the application of COFs as chromatographic stationary phase is still in the initial stage,the development of new stationary phase materials to achieve efficient separation is still an important problem to be solved in the field of separation science.COFs silica gel composite material(COFs-SiO2)combines the adjustable pore of COFs with the strong mechanical stability and pressure resistance of SiO2,showing great potential in the field of chromatographic separation.In this paper,the advantages of COFs as stationary phase materials are summarized,and the design of COFs-SiO2 composites by different connection methods such as triazine ring,imine bond,hydrazone bond and boron bond and its application in the separation of chiral compounds,isomers and environmental pollutant are introduced in detail.The application prospect of COFs-SiO2 in high performance liquid chromatography was further prospected.关键词
共价有机框架/高效液相色谱/固定相/复合材料Key words
Covalent organic framework/High-performance liquid chromatography/Stationary phase/Composite materials分类
化学引用本文复制引用
李振,汤紫霞,张洋洋,曹钰晨,付培可,吕美,王利涛..共价有机框架修饰硅胶复合材料在高效液相色谱中的研究进展[J].应用化学,2025,42(3):313-320,8.基金项目
山东省自然科学基金面上项目(No.ZR2019MB035)资助 Supported by the Natural Science Foundation of Shandong Province(No.ZR2019MB035) （No.ZR2019MB035）
