应用化学2025，Vol.42Issue(3)：386-395,10.DOI:10.19894/j.issn.1000-0518.240425
功能型聚乙二醇化壳聚糖纳米颗粒的制备和表征
Preparation and Investigation of Functional PEGylated Chitosan Nanoparticles
摘要
Abstract
In the present study,Carboxyl and azide terminated polyethylene(N3-PEG-COOH)with different relative molecular mass of 500 and 1000 were grafted onto the chitosan(CS)backbones through amide reaction,followed by the preparation of chitosan-polyethylene glycol(CS-PEG)nanoparticles with controllable size and zeta potential via sodium tripolyphosphate(TPP)ionotropic gelation.Characterized by Fourier transform infrared spectrometer(FT-IR),nuclear magnetic resonance spectroscopy(NMR)and thermal gravimetric analyzer(TGA)confirmed the successful incorporation of PEG,and the structures of the nanoparticles were analyzed by transmission electron microscopy(TEM)and nanoparticle size and zeta potential analyzer.The results demonstrated that when m(CS)∶m(TPP)is 3.33∶1,CS nanoparticles show excellent structural stability.Based on this,increasing the PEG grafting density further reduces the particle size and surface potential of CS-PEG nanoparticles.Moreover,the chemical reactivity of azide in CS-PEG nanoparticles was proved by the click reaction with alkyne-modified fluorescent molelule(5-FAM-alkyne),showing their potential as paltform for target drug delivery,fluorescent probes and other biomedical applications.关键词
壳聚糖/纳米颗粒/点击化学/离子凝胶法/聚合物荧光探针Key words
Chitosan/Nanoparticles/Click reaction/Ionotropic gelation/Polymer fluorescent probes分类
化学化工引用本文复制引用
肖巨颖,赵霞,林园,苏朝晖..功能型聚乙二醇化壳聚糖纳米颗粒的制备和表征[J].应用化学,2025,42(3):386-395,10.基金项目
国家自然科学基金(No.22175170)资助 Supported by the National Natural Science Foundation of China(No.22175170) （No.22175170）
