Abstract
Objective To explore the predictive value of platelet count(PLT),neutrophil-to-lymphocyte ratio(NLR),and serum procalcitonin(PCT)on the poor prognosis of patients with sepsis,providing a reference for clinical diagnosis and treatment.Methods A retrospective analysis was conducted on the clinical data of 100 sepsis patients admitted to the ICU of Hebi People's Hospital from July 2022 to July 2024.Based on the survival outcomes after 28 days,patients were divided into a survival group(55 cases)and a death group(45 cases).White blood cell count(WBC),C-reactive protein(CRP),PCT,Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE II)score,PLT,and NLR were compared between the two groups.The value of PCT,NLR,and PLT in predicting poor prognosis in sepsis patients was analyzed,both individually and in combination.Results There were no statistically significant differences in age,gender,or infection site between the two groups(P＞0.05).The death group had higher levels of WBC,CRP,APACHE Ⅱ score,NLR,and PCT,and lower levels of PLT compared to the survival group,with all differences being statistically significant(P＜0.05).Multivariate logistic analysis showed that CRP,APACHE II score,PLT,NLR,and serum PCT were independent factors affecting mortality in sepsis patients(P＜0.05).Receiver Operating Characteristic(ROC)curve analysis indicated that the area under the curve(AUC)for CRP,APACHE Ⅱscore,PLT,NLR,PCT,and combined detection in predicting 28-day survival outcomes of sepsis patients were 0.763,0.85,0.741,0.869,0.850,and 0.986 respectively(P＜0.05).Conclusion PLT,NLR,and serum PCT levels can assist in predicting the prognosis of sepsis patients to some extent.The combined detection of CRP,APACHE II,PCT,NLR,and PLT provides a better assessment of sepsis prognosis compared to single-item detection.关键词
中性粒细胞与淋巴细胞比值/血小板计数/血清降钙素原/脓毒症/预后Key words
Neutrophil-to-lymphocyte ratio/platelet count/serum procalcitonin/sepsis/prognosis分类
医药卫生
