摘要
Abstract
Objective To analyze the efficacy of blood routine biochemical indicators,serum interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)in predicting adverse reactions after internal fixation surgery in fracture patients.Methods A retrospective collection of data from 96 fracture patients who underwent internal fixation surgery at the First Affiliated Hospital of Nanyang Medical College from January 2021 to December 2023 was conducted.Basic patient data—including demographic and clinical features—and results of blood routine indices,biochemical indicators,and serum inflammatory factor tests on the 3rd day post-surgery and one day before discharge were collected.Patients'prognostic outcomes within one year post-surgery were also documented.Results Among the analyzed patients,29 experienced poor prognosis(classified into the poor prognosis group)and 67 had a good prognosis(classified into the good prognosis group).On the 3rd day post-surgery,the poor prognosis group showed significantly higher levels of age,white blood cell count(WBC),neutrophil count(NEU),C-reactive protein(CRP),creatinine(Scr),IL-6,and TNF-α compared to the good prognosis group,with all differences being statistically significant(P<0.05).One day before discharge,higher levels of WBC,CRP,IL-6,and TNF-α and lower levels of hemoglobin(Hb)were observed in the poor prognosis group compared to the good prognosis group,with statistically significant differences(P<0.05).Binary logistic regression analysis showed that age,WBC,NEU,CRP,Scr,IL-6,TNF-α on the 3rd day post-surgery,and Hb,CRP,IL-6,TNF-α one day before discharge were influential factors affecting adverse prognosis,with statistically significant differences(P<0.05).ROC curve analysis on the 3rd day post-surgery indicated that NEU had moderate predictive value,IL-6 had good predictive value,and WBC and CRP had ideal predictive value for adverse prognosis,with statistically significant differences(P<0.05).ROC curve analysis one day before discharge showed that TNF-α and IL-6 had good predictive value,while CRP had ideal predictive value for adverse prognosis,all with statistically significant differences(P<0.05).Conclusion Age and levels of blood routine,biochemical,and serum inflammatory indicators in fracture patients undergoing internal fixation are closely related to adverse prognosis.A combined assessment using multiple indicators post-surgery can help in evaluating the risk of adverse prognosis and taking timely interventions,reducing the incidence of adverse events,and improving patient outcomes.关键词
骨折内固定术/血常规/白介素-6/肿瘤坏死因子-α/不良预后结局Key words
Fracture internal fixation surgery/blood routine/interleukin-6/tumor necrosis factor-α/adverse prognosis outcomes分类
医药卫生
