摘要
Abstract
Objective To explore the changes in vaginal microbiota in patients with gestational diabetes mellitus(GDM)and analyze its relationship with adverse perinatal outcomes.Methods A total of 112 GDM patients treated at Luoyang Peony Maternal and Child Hospital from February 2019 to January 2023 were selected as the study group,and another 112 healthy pregnant women were chosen as the control group.Based on the condition of vaginal dysbiosis and perinatal pregnancy outcomes,the study group was divided into a vaginal dysbiosis group(57 cases)and a normal vaginal microbiota group(55 cases),as well as a good outcome group(81 cases)and a poor outcome group(31 cases).The distribution of vaginal microbiota in the study group was compared to that in the control group.The pregnancy outcomes of the vaginal dysbiosis group were compared with those of the normal vaginal microbiota group,and the general information and vaginal microbiota distribution of the good outcome group were compared with those of the poor outcome group.Factors affecting adverse outcomes in perinatal infants of GDM patients were analyzed.Results The proportion of Lactobacillus in the study group was lower than that in the control group(P＜0.05),while the proportions of Gram-positive rods,Gram-negative rods,Gram-positive cocci,Escherichia coli,Candida albicans,with a microbiota density of level Ⅰ/Ⅳ,microbiota diversity of level Ⅰ/Ⅳ dysbiosis,and pH＞4.5 were higher than those in the control group(P＜0.05).The incidence of adverse pregnancy outcomes such as preterm birth,neonatal jaundice,and neonatal infection in the vaginal dysbiosis group was higher than that in the normal vaginal microbiota group(P＜0.05).Factors such as age＞35 years,elevated glycated hemoglobin(HbA1c),elevated fasting blood glucose,reduced Lactobacillus,increased Gram-positive rods,Gram-negative rods,Gram-positive cocci,Escherichia coli,Candida albicans,a vaginal microbiota density of level Ⅰ/Ⅳ,microbiota diversity of level Ⅰ/Ⅳ dysbiosis,and pH＞4.5 were all identified as influencing factors for adverse perinatal outcomes in GDM(P＜0.05).Conclusion Changes in vaginal microbiota and microecology in GDM patients are associated with adverse perinatal outcomes.关键词
妊娠期糖尿病/阴道菌群/围产儿/不良妊娠结局Key words
Gestational Diabetes Mellitus/Vaginal Microbiota/Perinatal/Adverse Pregnancy Outcomes分类
医药卫生
