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CRTC3 restricts SARS-CoV-2 replication and is antagonized by CREB

Li Yang Yong-Tang Zheng Wei Cheng Xiao-Tao Zeng Rong-Hua Luo Ying Tang Si-Xue Ren Xin-Yan Long Xiang-Hui Fu Wan-Jiang Zhang Hai-Yan Ren

中国病毒学2025，Vol.40Issue(1)：92-108,17.

中国病毒学2025，Vol.40Issue(1)：92-108,17.DOI:10.1016/j.virs.2024.12.006

CRTC3 restricts SARS-CoV-2 replication and is antagonized by CREB

Li Yang ¹Yong-Tang Zheng ²Wei Cheng ¹Xiao-Tao Zeng ³Rong-Hua Luo ²Ying Tang ¹Si-Xue Ren ¹Xin-Yan Long ²Xiang-Hui Fu ⁴Wan-Jiang Zhang ⁵Hai-Yan Ren¹

作者信息

1. Department of Pulmonary and Critical Care Medicine,Respiratory Infection and Intervention Laboratory of Frontiers Science Center for Disease-related Molecular Network,and State Key Laboratory of Biotherapy,West China Hospital of Sichuan University,Chengdu 610041,China
2. State Key Laboratory of Genetic Evolution&Animal Models,Key Laboratory of Bioactive Peptides of Yunnan Province,KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases,Center for Biosafety Mega-Science,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming 650201,China
3. Department of Pulmonary and Critical Care Medicine,Respiratory Infection and Intervention Laboratory of Frontiers Science Center for Disease-related Molecular Network,and State Key Laboratory of Biotherapy,West China Hospital of Sichuan University,Chengdu 610041,China||Research and Innovation Center,Pengzhou People's Hospital,Pengzhou 610000,China
4. Department of Biotherapy,Center for Diabetes and Metabolism Research,State Key Laboratory of Biotherapy and Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,China
5. Department of Pathophysiology,Shihezi University School of Medicine,The Key Laboratory of Xinjiang Endemic and Ethnic Diseases,Shihezi 832003,China
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摘要

关键词

Human coronaviruses(HCoVs)/RNA-Dependent RNA polymerase(RdRp)/CREB-regulated transcription coactivator 3(CRTC3)/Virus replication/Virus-host interaction/Cyclic AMP response element-binding protein(CREB)

Key words

引用本文复制引用

Li Yang,Yong-Tang Zheng,Wei Cheng,Xiao-Tao Zeng,Rong-Hua Luo,Ying Tang,Si-Xue Ren,Xin-Yan Long,Xiang-Hui Fu,Wan-Jiang Zhang,Hai-Yan Ren..CRTC3 restricts SARS-CoV-2 replication and is antagonized by CREB[J].中国病毒学,2025,40(1):92-108,17.

基金项目

This work is supported by grants from the National Natural Science Foundation of China(32071236),the National Science Fund for Distin-guished Young Scholars(32225001),the 1.3.5 Project for Disciplines Excellence of West China Hospital,Sichuan University(ZYGD23018),Key Science and Technology Research Projects in Key Areas of the Corps(2023AB053),the National Key Research and Development Program of China(2022YFC2303700),the Joint Project of Pengzhou People's Hos-pital with Southwest Medical University(2024PZXNYD02),Project funded by China Postdoctoral Science Foundation(2020M683304),Sichuan Science and Technology Support Project(2021YJ0502)and Post-Doctor Research Project,West China Hospital,Sichuan University(2020HXBH082).We thank Kunming National High-level Biosafety Research Center for Non-human Primates,Center for Biosafety Mega-Science,Kunming Institute of Zoology,for providing the experimental platform.We thank Hai-Yan Ren and Xiang-Hui Fu for providing HEK293T and HEK293T-ACE2 cells.We thank Li-Chuan Gu for providing plasmids pET32a-NSP8,pET21b-NSP7 and pET21b-NSP12.The authors would like to express their heartfelt gratitude to Hui-Fang Li(Core Fa-cility of West China Hospital)for her help with the flow cytometry. （32071236）

中国病毒学

ISSN：1003-5125

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