中国康复2025，Vol.40Issue(4)：223-228,6.DOI:10.3870/zgkf.2025.04.006
非小细胞肺癌合并冠心病患者运动耐量、通气效率特点的临床研究
Characteristics of exercise tolerance and ventilatory efficiency in patients with non-small cell lung cancer complicated with coronary heart disease
摘要
Abstract
Objective:To explore the characteristics of cardiopulmonary function during cardiopulmonary exercise testing(CPET)in patients with non-small cell lung cancer(NSCLC)complicated with coronary heart disease(CHD).Methods:From November 2020 to June 2022,a total of 60 patients with NSCLC complicated with CHD who were admitted for the first time to the Department of Thoracic Surgery at Xuzhou Central Hospital were select-ed as the experimental group.Then,using propensity score matching with a ratio of 1∶1 in the Department of Tho-racic Surgery database and electronic medical record database,60 patients with pure lung cancer(non-NSCLC CHD group)were matched as the control group,with matching criteria including gender,age,body mass index,smoking history,exercise habits,lung cancer pathological type,and clinical stage.The specific indicators of CPET were col-lected from both groups for comparative analysis,and the experimental results were observed.Results:Comparison of core indicators of CPET between the two groups revealed that in the NSCLC-CHD group,peak WR,peak VO2,peak VO2/pred％,and peak VO2/kg were lower than those in the non-NSCLC CHD group,while VE/VCO2slope and VE/VCO2 nadir were higher than those in the non-NSCLC CHD group.The differences between the two groups were statistically significant(P＜0.05).There was no statistically significant difference in AT,peak O2 pulse,and RERpeak between the two groups(P＜0.05).Comparison of four stage indexes of CPET between the two groups showed that VO2(peak),VCO2(peak),PETCO2(four stages)and heart rate recovery value(1-4 mins)in NSCLC-CHD group were lower than those in non-NSCLC CHD group,while VE/VCO2(peak value),heart rate(warm up,AT)were higher than those in non-NSCLC CHD group.The difference was statistically significant(P＜0.05).The comparison of static lung function indicators be-tween the two groups indicated that in the NSCLC-CHD group,forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC ra-tio,maximum voluntary ventilation(MVV),peak expira-tory flow(PEF),and their percentage of predicted values(FEV1％,FVC％,MVV％,PEF％)were all lower than those in the non-NSCLC CHD group(P＜0.05),and the differences were statistically significant.Conclusion:Exercise tolerance and ventilation efficiency of NSCLC-CHD patients were worse than those without CHD.CPET can provide a basis for pre-pneumonectomy risk assessment in NSCLC patients with CHD.关键词
非小细胞肺癌/冠心病/心肺运动试验/通气效率/运动耐量Key words
non-small cell lung cancer/coronary artery disease/cardiopulmonary exercise testing/ventilatory ef-ficiency/exercise tolerance分类
临床医学引用本文复制引用
冉欣,姜效韦,陈伟,李瑾..非小细胞肺癌合并冠心病患者运动耐量、通气效率特点的临床研究[J].中国康复,2025,40(4):223-228,6.基金项目
徐州市科技计划项目(KC20136) （KC20136）
