中国康复2025，Vol.40Issue(4)：240-248,9.DOI:10.3870/zgkf.2025.04.009
不同刺激频率的重复经颅磁刺激治疗帕金森病疗效的网状Meta分析
Efficacy of repetitive transcranial magnetic stimulation with different stimulation frequencies in the treatment of Par-kinson's disease:a network meta-analysis
摘要
Abstract
Objective:To compare the effects of different frequencies of repetitive transcranial magnetic stimulation on patients with Parkinson's disease(PD)by network Meta-analysis.Methods:Randomized controlled trials of rT-MS on Parkinson's patients were retrieved from CNKI,Wanfang database,VIP,Chinese biomedical literature data-base,PubMed,Embase,Cochranelibrary,Web of science and other databases.The search was from January 1,2014 to June 1,2024.Revman was used to evaluate the quality of the included studies.R software and Stata were used for data analysis.Results:A total of 16 articles were included in the analysis,including 959 PD patients.The frequency of rTMS included 0.1 Hz,1 Hz,5 Hz,10 Hz,20 Hz and 25 Hz.The results of network Meta-analysis suggested that 0.1 Hz rTMS,1 Hz rTMS and 5 Hz rTMS could improve unified Parkinson's disease rating scale part Ⅲ(UPDRS Ⅲ)score,1 Hz rTMS and 5 Hz rTMS could improve timed up and go test(TUG)score,1 Hz rT-MS,5 Hz rTMS and 10 Hz rTMS could improve Hamilton depression scale(HAMD)score.5 Hz rTMS and 20 Hz rTMS could improve the Parkinson's disease questionnaire-39(PDQ-39)score of patients,and 1 Hz rTMS,5 Hz rTMS and 20 Hz rTMS could improve the scales for outcomes in Parkinson's disease-autonomic(SCOPA-AUT)score of patients.5 Hz rTMS had the best effect on UPDRS Ⅲ,TUG,HAMD and SCOPA-AUT,and 20 Hz rT-MS had the best effect on PDQ-39.Conclusion:Based on the current research,we can conclude that rTMS can im-prove UPDRS Ⅲ,TUG,HAMD,PDQ-39 and SCOPA-AUT in PD patients,and 5 Hz rTMS has the best effect on UPDRS Ⅲ,TUG,HAMD and SCOPA-AUT,and 20 Hz rTMS has the best effect on PDQ-39.关键词
重复经颅磁刺激/帕金森患者/频率/贝叶斯网状Meta分析Key words
transcranial magnetic stimulation/Par-kinson's disease/frequency/Bayesian network Meta-a-nalysis分类
医药卫生引用本文复制引用
韩靓,席晓明,王贺,阚梦凡,于少泓..不同刺激频率的重复经颅磁刺激治疗帕金森病疗效的网状Meta分析[J].中国康复,2025,40(4):240-248,9.基金项目
教育部产学合作协同育人项目(202102424004) （202102424004）
首都医科大学附属北京康复医院引进人才科研启动基金(2022R-006) （2022R-006）
