中国口腔种植学杂志2025，Vol.30Issue(2)：118-126,9.DOI:10.12337/zgkqzzxzz.2025.04.005
富血小板纤维蛋白促进骨再生效果的研究
Effect of platelet-rich fibrin on bone regeneration
摘要
Abstract
Platelet-rich fibrin(PRF),a second-generation autologous platelet concentrate,has been widely used in oral implantology and maxillofacial surgery due to its excellent biocompatibility and bone regeneration capacity.PRF facilitates osteoblast activation,angiogenesis,and bone remodeling by sustained release of growth factors through its three-dimensional fibrin network.It has shown significant potential in sinus floor elevation,bone augmentation,extraction site preservation,and immediate implant placement,improving implant stability and survival rates.Additionally,PRF has shown efficacy in the treatment of medication-related osteonecrosis of the jaw(MRONJ)by reducing infection,alleviating inflammation,and promoting tissue healing.However,PRF's clinical outcomes are influenced by individual physiological differences,preparation methods,and degradation rates.PRF's long-term osteogenic effects,especially in severe bone defects,remain inconsistent.Optimizing centrifugation parameters,blood collection tube materials,and fiber structure,as well as combining PRF with bone grafts,antimicrobial drugs,and biomimetic scaffolds,can enhance its performance.Additionally,PRF combined with nanomaterials and hydrogel scaffolds shows potential advantages in angiogenesis and tissue regeneration,though long-term follow-up data remain limited.In conclusion,PRF holds significant promise in bone regeneration.However,further studies are required to establish standardized preparation protocols and multidisciplinary strategies to improve its clinical stability and efficacy.关键词
富血小板纤维蛋白/上颌窦底提升/牙槽嵴保存/即刻种植/药物相关性颌骨坏死Key words
Platelet-rich fibrin(PRF)/Sinus floor elevation/Alveolar ridge preservation/Immediate implant placement/Medication-related osteonecrosis of the jaw(MRONJ)引用本文复制引用
黄李蓉,冯泽儒,吴红崑,莫安春..富血小板纤维蛋白促进骨再生效果的研究[J].中国口腔种植学杂志,2025,30(2):118-126,9.基金项目
国家重点研发计划重点项目(2023YFC2413603) （2023YFC2413603）
四川省科技厅重点研发项目(2024YFFK0294) National Key R&D Plan(2023YFC2413603) （2024YFFK0294）
Key R&D Projects of the Department of Science and Technology of Sichuan Province(2024YFFK0294) （2024YFFK0294）
