中国临床药理学杂志2025，Vol.41Issue(3)：410-415,6.DOI:10.13699/j.cnki.1001-6821.2025.03.023
内皮细胞与心肌细胞交互对话参与阿霉素心脏毒性的研究进展
Research progress of the involvement of the cross-talk between endothelial cells and cardiomyocytes in doxorubicin-induced cardiotoxicity
摘要
Abstract
Doxorubicin is widely used as a first-line therapeutic option in the treatment of several malignant tumors,but its clinical application is severely limited by the dose-dependent and irreversible cardiotoxicity,which has been a long-standing clinical challenge.We analyze the latest clinical guidelines on oncological cardiology and summarize the current status of doxorubicin-induced cardiotoxicity(DIC)prevention and treatment.On this basis,we have gone beyond the traditional view of direct damage to cardiomyocytes,and reviewed the research progress in recent years on the cross-talk between cardiac vascular endothelial cells and cardiomyocytes involved in DIC.The results suggest that cardiac endothelial cells play a key role in the development and maintenance of cardiac function.Doxorubicin not only directly damages these cells,but also disrupts the paracrine signals and physical barriers between them and cardiomyocytes,ultimately leading to an imbalance in cell communication and affecting cardiomyocyte survival and function,resulting in DIC.关键词
阿霉素心脏毒性/心肌细胞/内皮细胞/旁分泌/物理屏障Key words
doxorubicin-induced cardiotoxicity/cardiomyocyte/endothelial cell/paracrine/physical barriers分类
医药卫生引用本文复制引用
瞿礼萍,闵志强,张珵,彭希,刘晓帅,邹文俊..内皮细胞与心肌细胞交互对话参与阿霉素心脏毒性的研究进展[J].中国临床药理学杂志,2025,41(3):410-415,6.基金项目
国家自然科学基金资助项目(82274324) （82274324）
四川省自然科学基金杰出青年科学基金资助项目(2024NSFJQ0045) （2024NSFJQ0045）
