中国临床药理学杂志2025，Vol.41Issue(3)：422-427,6.DOI:10.13699/j.cnki.1001-6821.2025.03.025
中药单体调控TLR4/NF-κB信号通路治疗肝癌的研究现状
Research status of traditional Chinese medicine monomer components regulating TLR4/NF-κB signaling pathway in the treatment of liver cancer
摘要
Abstract
Toll-like receptor 4(TLR4)/nuclear factor-κB(NF-κB)signaling pathway plays an important role in invasion,proliferation,migration,apoptosis and autophagy of hepatocellular carcinoma cells.Traditional Chinese medicine(TCM)monomers inhibit M2 macrophage polarization,epithelial-mesenchymal transformation(EMT),snail family transcriptional repressor 2(SLUG)deubiquitination by ubiquitin-specific proteases(USP)and lipopolysaccharide(LPS)-induced cell damage by intervening TLR4/NF-κB signaling pathway.Serum inflammatory chemokine ligand 1(CXCL1)level and cyclooxygenase-2(COX-2)protein level were significantly decreased and matrixmetalloprotease-9(MMP-9)protein level was significantly decreased.The expression of MMP-9,decreased the levels of granulocyte-macrophage colony-stimulating factor(GM-CSF)and granulocyte colony-stimulating factor(G-CSF),and interfered with mitochondrial membrane potential(MMP),thereby inhibiting tumor cell invasion and migration,and promoting autophagy and apoptosis of hepatoma cells.The main purpose of this review is to update the latest TCM monomer components that exert anti-liver cancer effect through TLR4/NF-κB signaling,and to clarify the main mechanism of their action on liver cancer,and to provide ideas and methods for exploring more TCM with anti-liver cancer properties,so as to better promote the further development and utilization of TCM resources.关键词
中药单体/Toll样受体4/核转录因子-κB信号通路/肝癌Key words
traditional Chinese medicine monomer/Toll-like receptor 4/nuclear factor-κB signaling pathway/liver cancer分类
医药卫生引用本文复制引用
张宗博,马国婧,脱伟旺,海杰,杨红娟,田旭东..中药单体调控TLR4/NF-κB信号通路治疗肝癌的研究现状[J].中国临床药理学杂志,2025,41(3):422-427,6.基金项目
甘肃省名中医传承工作室基金资助项目(国中医药规财函[2021]242号) （国中医药规财函[2021]242号）
