中国临床药理学杂志2025，Vol.41Issue(3)：438-441,4.DOI:10.13699/j.cnki.1001-6821.2025.03.028
Notch信号通路在类风湿关节炎病理机制中的研究现状
Research status of the Notch signaling pathway in the pathogenesis of rheumatoid arthritis
摘要
Abstract
Rheumatoid arthritis(RA)is categorized as"bi zheng"and"li-jiebing"in Chinese medicine.Liver and kidney insufficiency,marrow can not nourish the bones,feel the external evil,long-term accumulation in the body,heat into poison,damage to the qi and blood meridians and collaterals,heat and poison,phlegm,blood stasis and paralysis and the onset of the disease,mixed with the real and the imaginary,difficult to be cured.The Notch signaling pathway has a greater relevance to this disease,and it is involved in various pathological processes such as inflammatory cell infiltration,proliferation of fibroblast-like synoviocytes(FLS),microvascular formation and bone destruction.In this paper,the correlation between Notch signaling pathway and this disease is discussed from the perspective of the combination of Chinese and Western medicine,based on the theory of"XU,DU,YU"of traditional Chinese medicine,with the aim of providing a new way of thinking for the research.关键词
类风湿关节炎/Notch信号通路/虚毒瘀/中西医结合Key words
rheumatoid arthritis/Notch signal path/Xu,Du and Yu/combination of Chinese and Western medicine分类
医药卫生引用本文复制引用
漆文霞,王嘉,贺童,田杰祥,王涛,闫彦峰,张媛媛,王钢..Notch信号通路在类风湿关节炎病理机制中的研究现状[J].中国临床药理学杂志,2025,41(3):438-441,4.基金项目
国家自然科学基金资助项目(81860858、81960832) （81860858、81960832）
甘肃省科技基金资助项目(22JR11RA131) （22JR11RA131）
