摘要
Abstract
Objective To observe the clinical efficacy of medroxyprogesterone acetate and dinogestrel in the treatment of endometriosis(EMs)respectively.Methods EMs patients were divided into control group and treatment group according to cohort methods.Control group was given oral treatment with medroxyprogesterone acetate tablets,10 mg each time,tid.Treatment group was given oral treatment with dinorgestrel tablets,2 mg each time,qd.Patients in both groups continued to take the drug for 6 menstrual cycles.The levels of clinical efficacy,basal follicle-stimulating hormone(bF-SH),basal estradiol(b E2),anral follicle count(AFC)and anti-mullerian hormone(AMH)before and after treatment were compared between the two groups.Results In this trial,38 cases were enrolled in the control group and 42 cases in the treatment group.After treatment,the total effective rates of the treatment group and the control group were 90.48％(38 cases/42 cases)and 71.05％(27 cases/38 cases),respectively,and the difference was statistically significant(P＜0.05).After treatment,the levels of bF-SH in the treatment group and control group were(11.25±3.02)and(13.41±3.56)IU·L-1,respectively;the bE2 levels were(2.14±0.63)and(2.58±0.87)pmol·L-1,respectively;the AFC levels were 7.80±1.69 and 6.97±1.63,respectively;the AMH levels were(1.12±0.14)and(1.03±0.21)ng·mL-1,respectively;the above indexes were statistically significant(P＜0.01,P＜0.001).The adverse drug reactions of the treatment group mainly included abnormal vaginal bleeding,hot flashes and increased body weight,while the adverse drug reactions of the control group mainly included bleeding and hot flashes.The incidence of total adverse drug reactions in the treatment group and the control group was 11.90％(5 cases/42 cases)and 7.89％(3 cases/38 cases),respectively,and the difference was not statistically significant(P＞0.05).Conclusion Dienogest tablets has a good effect in the treatment of EMs patients,which can effectively relieve pain symptoms,inhibit estrogen expression,improve uterine artery blood flow,and reduce the level of inflammation in the body,with low adverse drug reactions.关键词
醋酸甲羟孕酮片/地诺孕素片/子宫内膜异位症/孕激素/雌激素/子宫动脉血流动力学Key words
medroxyprogesterone acetate tablet/dinorgestrel tablet/endometriosis/progestogens/estrogen/uterine artery hemodynamics分类
药学
