中国临床药理学杂志2025，Vol.41Issue(5)：626-630,5.DOI:10.13699/j.cnki.1001-6821.2025.05.006
瑞马唑仑联合阿芬太尼用于宫腔镜手术患者的临床研究
Clinical trial of remazolam combined with alfentanil in the treatment of patients with hysteroscopic surgery
摘要
Abstract
Objective To observe the anesthetic effects and safety of remazolam injection combined with alfentanil injection in the treatment of patients with hysteroscopic surgery.Methods Patients scheduled for hysteroscopic surgery were randomly divided into control group and treatment group.The control group received intravenous 1.5-2.0 mg·kg-1 propofol+7-10 μg·kg-1 alfentanil for anesthetic induction,during the surgery,continuously infused with 4-12 mg·kg-1·h-1 propofol+0.05-0.20 μg·kg-1·h-1 remifentanil for anesthesia maintenance.The treatment group was given intravenous 0.3-0.5 mg·kg-1 remimazolam+7-10 μg·kg-1 alfentanil for anesthetic induction,during the surgery,received 0.5-1.0 mg·kg-1·h-1 remazolam+0.05-0.20 μg·kg-1·h-1 remifentanil for anesthesia maintenance.The hemodynamics,analgesic effects,cognitive function and safety were compared between the two groups.Results Control group were enrolled 52 cases,3 cases dropped out,and 49 cases were finally included in the statistical analysis.Treatment group were enrolled 53 cases,4 cases dropped out,and 49 cases were finally included in the statistical analysis.At the end of the surgery,the mean arterial pressure of treatment and control groups were(73.98±7.41)and(60.10±6.84)mmHg,the heart rates were(68.43±7.32)and(63.92±7.36)beat·min-1,the differences of above index were statistically significant between two groups(all P＜0.05).One hour after operation,the visual analogue scale scores of treatment and control groups were(3.08±0.49)and(3.86±0.61)points,the mini-mental state examination scores were(22.65±2.41)and(18.24±2.38)points,the differences were statistically significant(all P＜0.05).The adverse drug reactions of treatment group were nausea,while those in the control group were bradycardia,hypotension,respiratory depression and nausea.The total incidences of adverse drug reactions in the treatment and control groups were 2.04％and 14.29％,with statistically significant difference(P＜0.05).Conclusion Remazolam injection combined with alfentanil injection can help to maintain hemodynamics of patients with hysteroscopic surgery,reduce the risk of postoperative pain and cognitive impairment,with good safety.关键词
瑞马唑仑注射液/阿芬太尼注射液/丙泊酚注射液/宫腔镜手术/安全性评价Key words
remazolam injection/alfentanil injection/propofol injection/hysteroscopic surgery/safety evaluation分类
药学引用本文复制引用
许克路,沈勤,吴桐,程玥..瑞马唑仑联合阿芬太尼用于宫腔镜手术患者的临床研究[J].中国临床药理学杂志,2025,41(5):626-630,5.基金项目
安徽省自然科学基金资助项目(20210319) （20210319）
