中国临床药理学杂志2025，Vol.41Issue(5)：722-726,5.DOI:10.13699/j.cnki.1001-6821.2025.05.024
STAT3介导的信号网络调控哮喘气道重塑的研究现状
Research status of STAT3-mediated signaling network regulation of airway remodeling in asthma
摘要
Abstract
Airway remodeling is one of the pathological features of asthma and the direct cause of irreversible decline in lung function in asthma patients.Signal transducer and activator of transcription 3(STAT3)can drive the differentiation of helper tlymphocyt(Th)2 and Th17 cells and the expression of cytokines.It plays a key regulatory role in airway remodeling processes such as metaplasia of bronchial epithelial goblet cells(GC),deposition of extracellular matrix(ECM),and epithelial mesenchymal transition(EMT)induced by proliferation of airway smooth muscle cells(ASMCs)in asthma.Therefore,the regulation of asthma airway remodeling related signal networks by STAT3 has become a new research hotspot in recent years.This article reviews the mechanism of STAT3 in regulating asthma airway remodeling from the perspective of signaling networks such as Janus kinase 2(JAK2),nuclear factor kappa B(NF-κB),transforming growth factor-β1(TGF-β1),interleukin-17(IL-17),IL-6,providing a theoretical basis for the study of asthma airway remodeling mechanisms and the development of new drugs.关键词
支气管哮喘/气道重塑/信号转导与转录激活因子3/信号网络Key words
bronchial asthma/airway remodeling/signal transducer and activator of transcription 3/signaling network分类
医药卫生引用本文复制引用
张悦,王志旺,黄柯婷,梁可克,赵跃,全苹..STAT3介导的信号网络调控哮喘气道重塑的研究现状[J].中国临床药理学杂志,2025,41(5):722-726,5.基金项目
国家自然科学基金资助项目(82260852、81460668) （82260852、81460668）
甘肃省自然科学基金资助项目(20JR5RA183、1606RJZA011、1310RJZA086) （20JR5RA183、1606RJZA011、1310RJZA086）
甘肃省高校研究生"创新之星"基金资助项目(2025CXZX-934) （2025CXZX-934）
