中国临床药理学杂志2025，Vol.41Issue(5)：727-731,5.DOI:10.13699/j.cnki.1001-6821.2025.05.025
中医药通过调控Keap1/Nrf2信号通路对急性肺损伤氧化应激的保护作用
Protective effects of traditional Chinese medicine against oxidative stress in acute lung injury by modulating Keap1/Nrf2 signal pathway
摘要
Abstract
Objective Acute lung injury(ALI)/acute respiratory distress syndrome is a life-threatening acute diffuse inflammatory lung injury characterised by increased pulmonary vascular permeability,inflammatory cell infiltration,pulmonary oedema,diffuse alveolar damage and reduced respiratory output.Its pathogenesis is complex,and oxidative stress is a key mechanism leading to ALI exacerbated by alveolar epithelial cell dysfunction.The Kelch-like ECH associated protein 1/nuclear factor-E2-related factor 2(Keap1/Nrf2)signalling pathway is an important signalling pathway of traditional Chinese medicine in the treatment of ALI by regulating oxidative stress.This paper analyses and summarizes the relevant Chinese medicine formulas and active ingredients for the treatment of ALI,and finds that a large number of antioxidant active ingredients can regulate oxidative stress through the Keap1/Nrf2 signaling pathway and play a role in improving ALI,which also provides a basis for the prevention and treatment of ALI disease and further drug development.关键词
中医药/急性肺损伤/Kelch环氧氯丙烷相关蛋白1/核因子E2相关因子2/氧化应激Key words
Chinese medicine/acute lung injury/Kelch-like ECH associated protein 1/nuclear factor-E2-related factor 2/oxidative stress分类
医药卫生引用本文复制引用
郝国雄,靳晓杰,徐倩,万家宜,梁夏丽,张丽敏,张志明..中医药通过调控Keap1/Nrf2信号通路对急性肺损伤氧化应激的保护作用[J].中国临床药理学杂志,2025,41(5):727-731,5.基金项目
甘肃省自然科学基金资助项目(23JRRA1241) （23JRRA1241）
甘肃省科技计划重大专项基金资助项目(甘科计[2022]1号-25) （甘科计[2022]1号-25）
兰州市人才创新创业基金资助项目(2021-RC-80) （2021-RC-80）
兰州市科技计划基金资助项目(2023-2-91) （2023-2-91）
