中国临床药理学杂志2025，Vol.41Issue(5)：732-736,5.DOI:10.13699/j.cnki.1001-6821.2025.05.026
Sirtuins在肝星状细胞能量代谢中的作用
Roles of Sirtuins in energy metabolism of hepatic stellate cells
摘要
Abstract
Liver fibrosis is caused by various chronic injuries and metabolic disorders.Cirrhosis is the end stage of progressive liver fibrosis,which is estimated to affect 1％-2％of the global population and cause more than 1 million deaths worldwide every year.Activation and maintenance of hepatic stellate cells(HSCs)are the main driving factors in liver fibrosis.At the same time,the process of trans-differentiation of HSCs involves reprogramming of energy metabolism,which is a key metabolic feature necessary to promote cell growth.Current studies found that Sirtuin protein family plays an important role in the progress of liver fibrosis,and further found that in the progress of liver fibrosis,especially after HSCs activation.Energy metabolism reprogramming involves various cells,including liver cells,HSCs,and immune cells.Targeting intracellular metabolism to limit fibrosis progression is currently a research hotspot.This article reviews the regulatory role of the Sirtuin protein family in energy metabolism in HSCs.关键词
肝纤维化/肝星状细胞/沉默信息调节蛋白/代谢重编程Key words
liver fibrosis/hepatic stellate cells/silencing signaling regulatory proteins/metabolic reprogramming分类
医药卫生引用本文复制引用
尹晓春,陈璐,施瑞华..Sirtuins在肝星状细胞能量代谢中的作用[J].中国临床药理学杂志,2025,41(5):732-736,5.基金项目
中国博士后科学基金资助项目(2024M760449) （2024M760449）
