中国免疫学杂志2025，Vol.41Issue(4)：938-942,5.DOI:10.3969/j.issn.1000-484X.2025.04.027
反复种植失败患者慢性子宫内膜炎与外周血免疫指标的相关性研究
Correlation between chronic endometritis and peripheral blood immune indexes in patients with repeated implantation failure
摘要
Abstract
Objective:To investigate the prevalence of chronic endometritis(CE)in patients with repeated implantation failure(RIF),and the correlation between diagnostic indexes of CE and classification of peripheral blood immune cells.Methods:A total of 64 patients with RIF who visited Outpatient of Hebei Reproductive Health Hospital from January 2020 to December 2021 were retrospec-tively analyzed.General information of patients,results of hysteroscopy and endometrial immunohistochemistry in the mid luteal phase,the number and percentage of NK cells,Th1 cells,Th2 cells,Th17 cells and Treg cells in peripheral blood,and Th1/Th2,Th17/Treg were collected,and the pregnancy outcome of retransplantation was followed up.To evaluate the consistency of hysteroscopy and endometrial immunohistochemistry CD138 in diagnosis of CE in RIF patients,to analyze whether chronic inflammation of endome-trium was related to classification of peripheral blood immune cells,and to analyze the pregnancy outcome of patients with RIF diag-nosed with CE after retransplantation.Results:Prevalence of CE in RIF patients detected by hysteroscopy was 53.12%,which was sig-nificantly higher than that detected by endometrial immunohistochemistry CD138(25.00%,P<0.05).There was no significant differ-ence in the number and percentage of immune cells in peripheral blood between CE and non CE patients.After antibiotic treatment,the 12-week continuous pregnancy rate and live birth rate in the CD138 positive group were higher than those in negative group,with a statistically significant difference(P<0.05).Conclusion:The combination of hysteroscopy and endometrial CD138 immunohistochem-istry at the right time for RIF patients is beneficial to improve their pregnancy rate and pregnancy outcome.The infiltration of endome-trial plasma cells does not affect the classification of peripheral blood immune cells.关键词
反复种植失败/慢性子宫内膜炎/宫腔镜/CD138/外周血免疫细胞Key words
Repeated implantation failure/Chronic endometritis/Hysteroscopy/CD138/Peripheral blood immune cell分类
医药卫生引用本文复制引用
吴纯,茹慧波,董九华,王琇,张素芝,王树松,杜丽荣..反复种植失败患者慢性子宫内膜炎与外周血免疫指标的相关性研究[J].中国免疫学杂志,2025,41(4):938-942,5.基金项目
河北省科技计划项目(223777151D,21377799D) （223777151D,21377799D）
河北省医学科学研究课题计划(20241720). （20241720）
