中国免疫学杂志2025，Vol.41Issue(4)：948-953,6.DOI:10.3969/j.issn.1000-484X.2025.04.029
血清IgG4检测在IgG4-RD诊治和转归中的应用研究
Application of serum IgG4 detection in diagnosis,treatment and prognosis of IgG4-RD
摘要
Abstract
Objective:To investigate the value of serum IgG4 detection in diagnosis,treatment,evaluation and outcome of IgG4-associated diseases(IgG4-RD).Methods:By integrating the clinical data of patients,retrospectively and systematically analyze the results of common laboratory examinations,imaging examinations,pathological examinations,etc.26 patients who were diagnosed with IgG4-RD in Huaian First Hospital Affiliated to Nanjing Medical University from March 2013 to October 2023.Results:The median age of onset was 65(31～90)years old,and the male to female ratio was 3.33∶1.The first three symptoms were abdominal discomfort,skin scleral yellow stain and fever.Patients mainly involved multiple organs,the most commonly involved organs were lung,pancreas,liver,kidney,bile duct.Compared with the control group,NLR,PLR,ESR,CRP,TBIL,DBIL,ALT,AST,GGT,IgG,IgA and IgM were all abnormally elevated in the first hematological,biochemical and immune tests of the patients,the difference was statisti-cally significant,while C3 and C4 were all decreased,but there was no statistical difference.The first IgG4 level of IgG4-RD patients was correlated with the length of hospitalization,the length of return visit,and the dynamic changes of IgG4 level after return visit.Conclusion:Serum IgG4 detection plays an important role in the diagnosis and treatment of IgG4-RD.In patients with abnormally high level of IgG4,those who are sensitive to high-dose glucocorticoid therapy have a faster decline in IgG4 levels and a longer duration of symptom remission.关键词
IgG相关性疾病(IgG4-RD)/免疫球蛋白G亚型/血清Key words
IgG-related diseases(IgG4-RD)/Immunoglobulin G subtype/Serum分类
医药卫生引用本文复制引用
杨艳艳,李赛男,夏雨鑫,姜玉章..血清IgG4检测在IgG4-RD诊治和转归中的应用研究[J].中国免疫学杂志,2025,41(4):948-953,6.基金项目
淮安市医学检验重点实验室(HAP202004). （HAP202004）
