中国免疫学杂志2025，Vol.41Issue(4)：990-997,8.DOI:10.3969/j.issn.1000-484X.2025.04.036
G-MDSCs在肿瘤和非肿瘤疾病中免疫调控作用的研究进展
Research advancements of immunomodulatory role of G-MDSCs in tumor and non-tumor diseases
摘要
Abstract
Granulocytic myeloid-derived suppressor cells(G-MDSCs)are the principal subsets of myeloid-derived suppressor cells(MDSCs),which involved in development and progression of a variety of tumor and non-tumor diseases.G-MDSCs mediated disfunction of immune effector cells(such as T cells and NK cells)through producing Arg-1,ROS,iNOS,etc.is major cause of its immunosuppressive function.To date,a large number of studies have focused on tumor-promoting effects of G-MDSCs.However,their complex immunomodulatory functions,especially their positive effects in diseases such as autoimmune arthritis,are often overlooked.Besides,G-MDSCs share the same origin and phenotype with neutrophils,but their immune functions are heterogeneous.Therefore,precision of G-MDSCs targeted therapy will be largely improved if the two can be accurately distinguished,though this field is still under exploration.At present,there are abundant experimental studies on G-MDSCs at home and abroad,mainly in tumors,but there are no domestic reports on the immunomodulatory function of G-MDSCs in tumors and non-tumor diseases.Therefore,in this review,we summarizes the different roles played by G-MDSCs in tumor and non-tumor diseases,in order to reveal the important and complex functions of G-MDSCs in immune regulation.关键词
G-MDSCs/肿瘤/非肿瘤疾病/免疫调控Key words
G-MDSCs/Tumor/Non-tumor diseases/Immunomodulation分类
医药卫生引用本文复制引用
刘燕,张飞,祝晓雯,朱杨壮壮,邹纯朴,胥孜杭..G-MDSCs在肿瘤和非肿瘤疾病中免疫调控作用的研究进展[J].中国免疫学杂志,2025,41(4):990-997,8.基金项目
国家自然科学基金青年科学基金(81804017,81802357) （81804017,81802357）
国家自然科学基金面上项目(82274229) （82274229）
上海市自然基金面上项目(20ZR1458500) （20ZR1458500）
上海市科技计划项目"上海市健康辨识与评估重点实验室"(21DZ2271000) （21DZ2271000）
上海中医药大学杏林青年学者人才计划(A2-X200050316). （A2-X200050316）
