中国免疫学杂志2025，Vol.41Issue(4)：998-1003,6.DOI:10.3969/j.issn.1000-484X.2025.04.037
小胶质细胞在酒精诱导的神经炎症中的作用
Role of microglia in alcohol-induced neuroinflammation
摘要
Abstract
Alcohol abuse is a global public health problem.Excessive drinking not only damages digestive tract,cardiovascu-lar and endocrine systems,but also damages central nervous system(CNS).Recent studies have shown that alcohol interacts with neu-roimmune system to alter neuroimmune signaling and molecular expression,thereby leading to neuroinflammation and regulating a wide range of brain functions.Microglia is main cell of CNS involved in neuroimmune responses.Microglia is activated by alcohol and acts on neurons,leading to neuropsychiatric diseases,such as neuronal loss,abnormal synaptic connections,cognitive decline and motor dysfunction.Alcohol chronically stimulates digestive tract and also affects microglia along gut-brain axis.Neural properties of microglia and related immune factors and their important roles in neuroinflammation provide a new insight into neuroimmune mecha-nisms underlying alcohol-induced changes in brain function and behavior.This review discusses progress of role of microglia and their immune signaling in alcohol-induced neuroinflammation,and provides theoretical basis for further research on neurobiological mecha-nism and treatment of alcohol abuse.关键词
酒精/神经炎症/小胶质细胞/免疫信号/肠-脑轴Key words
Alcohol/Neuroinflammation/Microglia/Immune signal/Gut-brain axis分类
医药卫生引用本文复制引用
田佳伟,尹午萌,王珂,王书豪,单云鹤,乔晓孟..小胶质细胞在酒精诱导的神经炎症中的作用[J].中国免疫学杂志,2025,41(4):998-1003,6.基金项目
国家自然科学基金青年项目(82101978) （82101978）
河南省自然科学基金(212300410260) （212300410260）
郑州大学大学生创新创业训练计划项目(2022cxcy674). （2022cxcy674）
