中国免疫学杂志2025，Vol.41Issue(4)：1016-1020,5.DOI:10.3969/j.issn.1000-484X.2025.04.040
淋巴细胞活化基因3及其在感染性疾病中作用的研究进展
Research progress of lymphocyte activation gene 3 and its role in infectious diseases
摘要
Abstract
Infectious diseases refer to various diseases caused by pathogens invading human body.Lymphocyte activation gene 3(LAG-3)is a negative immune checkpoint molecule similar to CD4.Most studies have found that LAG-3 plays a regulatory role in occurrence and development of infectious diseases(acquired immunodeficiency disease,active pulmonary tuberculosis,chronic hepa-titis B,falciparum malaria)via inhibiting activation and function of CD4+T and CD8+T cells,and can serve as an effective potential immunotherapy target.This article will summarize researches of LAG-3 and its roles in infectious disease.关键词
免疫检查点/LAG-3/感染性疾病/免疫调控Key words
Immune checkpoint/LAG-3/Infectious diseases/Immune regulation分类
基础医学引用本文复制引用
陈洁,徐俊驰,强锐,刘轩妙,陈慧,胥萍..淋巴细胞活化基因3及其在感染性疾病中作用的研究进展[J].中国免疫学杂志,2025,41(4):1016-1020,5.基金项目
国家自然科学基金青年科学基金(81900577) （81900577）
苏州市重点学科(SZXK201814) （SZXK201814）
江苏省卫生健康委科研项目面上项目(M2021066) （M2021066）
苏州市科技计划(SZS2020311,SLJ2021017,SLT2021012,SYS2020190). （SZS2020311,SLJ2021017,SLT2021012,SYS2020190）
