中国司法鉴定Issue(2)：31-39,9.DOI:10.3969/j.issn.1671-2072.2025.02.004
代谢组学在新精神活性物质研究中的应用
Application of Metabolomics in the Investigation of New Psychoactive Substances
摘要
Abstract
New psychoactive substances(NPS)pose a significant threat to public health and social stability due to their wide variety,rapid turnover,difficulty in identification and detection,and lagging risk assessment and legal regulation.Metabolomics is a powerful tool for studying systems biology,reflecting the biochemical processes occurring in biological systems through the qualitative and quantitative analysis of metabolites.This review summarises recent progress in the application of metabolomics in NPS research.By combining metabolomics with other research methods,we can explore the pharmacological mechanisms of NPS for treating Parkinson's disease,depression,and other neurological dysfunctions.We can also examine the mechanisms of NPS addiction,the toxic responses and mechanisms of different types of NPS.These studies can predict the psychopharmacological activity of NPS,identify potential therapeutic agents for neurological disorders,prevent or alleviate addiction,treat toxic reactions,and provide insights for further research on NPS.Although metabolomics in NPS is currently limited,its potential application is promising and requires further exploration.关键词
新精神活性物质(NPS)/代谢组学/药理作用/成瘾机制/毒性作用机制Key words
new psychoactive substance(NPS)/metabolomics/pharmacological function/addiction mechanism/toxicity mechanicm分类
政治法律引用本文复制引用
钱小雨,向平,严慧..代谢组学在新精神活性物质研究中的应用[J].中国司法鉴定,2025,(2):31-39,9.基金项目
国家重点研发计划(2022YFC3302003) （2022YFC3302003）
中央公益课题(GY2022G-2) （GY2022G-2）
上海市法医学重点实验室资助项目(21DZ2270800) （21DZ2270800）
上海市司法鉴定专业技术服务平台资助项目 （）
司法部司法鉴定重点实验室资助项目. （）
