中国司法鉴定Issue(2)：47-52,6.DOI:10.3969/j.issn.1671-2072.2025.02.006
合成大麻素ADB-BUTINACA在豚鼠体内的药代动力学研究
Pharmacokinetic Study of Synthetic Cannabinoid ADB-BUTINACA in Guinea Pigs
摘要
Abstract
Objective To investigate the pharmacokinetics of ADB-BUTINACA in guinea pigs after a single administration.Methods Sixteen guinea pigs were randomly divided into low-dose(0.l mg/kg)and high-dose(0.5 mg/kg)groups,and ADB-BUTINACA were administered intraperitoneally.The concentrations of ADB-BUTINACA and its metabolite ADB-BUTINACA acid were determined in blood samples collected at various time points(0.02,0.08,0.16,0.25,0.33,0.5,0.66,1,2,4,6,12,and 24 h),and in urine samples collected from 12 h to 24 h post-dosing using liquid chromatography-tandem mass spectrometry(LC-MS/MS).Pharmacokinetic parameters were calculated using pharmacokinetic software.Results After single doses,ADB-BUTINACA rapidly reached its peak concentration in blood and was quickly eliminated,while the concentration of ADB-BUTINACA acid remained below the limit of quantification.The Tmax values for ADB-BUTINACA in blood were 20.00 min and 23.75 min for the low-dose and high-dose groups,respectively.The Cmax values were 11.42 ng/mL and 21.37 ng/mL,respectively,and the T1/2 values were 33.85 min and 34.14 min,respectively.The metabolite was detected in urine samples collected from 12 h to 24 h post-dosing,while the parent compound was not detected.Conclusion The results of this study indicate that ADB-BUTINACA is rapidly absorbed and eliminated in guinea pigs,with peak blood concentrations occurring approximately 20 min after administration and becoming undetectable after 2 h,suggesting a short detection window.While the detection window of urine can be extended to be 12 h to 24 h.This study provides reference data for toxicological research and forensic identification practices involving ADB-BUTINACA.关键词
ADB-BUTINACA/液相色谱-串联质谱法/血药浓度/代谢动力学Key words
ADB-BUTINACA/LC-MS/MS/blood concentration/pharmacokinetics分类
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张佳丽,向平,王新颖,王鑫..合成大麻素ADB-BUTINACA在豚鼠体内的药代动力学研究[J].中国司法鉴定,2025,(2):47-52,6.基金项目
"十四五"国家重点研发计划(2022YFC3300903) （2022YFC3300903）
国家自然科学基金资助项目(82002000) （82002000）
上海市法医学重点实验室资助项目(21DZ2270800) （21DZ2270800）
上海市司法鉴定专业技术服务平台资助项目 （）
司法部司法鉴定重点实验室资助项目. （）
