中国兽医杂志2025，Vol.61Issue(4)：96-103,8.DOI:10.20157/j.cnki.zgsyzz.2025.04.013
黄曲霉毒素B1的毒代动力学和毒性作用研究进展
Research Progress on Toxicokinetics and Toxic Effects of Aflatoxin B1
摘要
Abstract
Aflatoxin B1(AFB1)is an extremely toxic mycotoxin produced by Aspergillus fungi and is widely present in grains and feed crops.Due to its high thermal stability and certain photostability,AFB1 is difficult to completely eliminate under conventional food processing and storage conditions,posing a major food safety hazard and severely threatening the livestock industry and public health.Consequently,the toxicokinetics and toxic mechanisms of AFB1 have been key research areas in food safety,with continuous new discoveries deepening the scientific understanding of this toxin.This paper reviews the major exposure pathways,in vivo bioactivation,and detoxification processes of AFB1,with a focus on the complex interactions between different cytochrome P450(CYP450)and AFB1 metabolites.Additionally,the latest research progress on AFB1-induced hepatotoxicity,nephrotoxicity,intestinal toxicity,and immunotoxicity is summarized.These insights provide a theoretical and scientific basis for the development of AFB1 detoxification strategies and the formulation of food safety standards.关键词
黄曲霉毒素B1/代谢/细胞色素P450酶/毒性Key words
aflatoxin B1/metabolism/cytochrome P450/toxicity分类
农业科技引用本文复制引用
张璐,韩镕博,沈佳雪,王霄,包永占,史万玉..黄曲霉毒素B1的毒代动力学和毒性作用研究进展[J].中国兽医杂志,2025,61(4):96-103,8.基金项目
"十四五"国家重点研发计划(2022YFD1801104) （2022YFD1801104）
河北省现代农业产业技术体系创新团队建设专项(HBCT2024110202) （HBCT2024110202）
河北省在读研究生创新能力培养资助项目(CXZZBS2025098) （CXZZBS2025098）
