中国体外循环杂志2025，Vol.23Issue(2)：108-112,5.DOI:10.13498/j.cnki.chin.j.ecc.2025.02.04
体外膜氧合支持患者病原菌分布的回顾性研究
Microbial profile in patients undergoing extracorporeal membrane oxygenation:a retrospective cohort study
陈武 1刘刚 2王靖 2王建 2王添隆 2滕媛 2吉冰洋2
作者信息
- 1. 100037 北京,中国医学科学院北京协和医学院国家心血管病中心阜外医院体外循环中心||563000 遵义,遵义医科大学第二附属医院重症医学科
- 2. 100037 北京,中国医学科学院北京协和医学院国家心血管病中心阜外医院体外循环中心
- 折叠
摘要
Abstract
Objective To retrospectively analyze the microbial distribution patterns in patients receiving extracorporeal membrane oxygenation(ECMO).Methods This single-center retrospective cohort study analyzed 95 patients with microbiologically confirmed infections during ECMO support at Fuwai Hospital from March 2017 to August 2022.Clinical data,pathogen profiles from specimens,infection biomarkers,ECMO parameters,and mortality outcomes were systematically evaluated.Results The cohort(mean age 51±14.4 years,62.1%male)predominantly received venoarterial ECMO(V-A ECMO:92/95).Respiratory specimens demonstrated the highest positivity rate(89/95,93.7%),followed by urinary(15/95,15.8%)and bloodstream infections(3/95,3.2%).Gram-negative bacilli(86 isolates)predominated,with Klebsiella pneumoniae(26.7%),Pseudomonas aeruginosa(22.1%),and multidrug-resistant Acinetobacter baumannii(18.6%)as leading pathogens.Gram-positive cocci(82 isolates)were primarily coagulase-negative staphylococci(34.1%),Staphylococcus aureus(29.3%),and Enterococcus spp.(19.5%).Fungal infections(64 isolates)featured Candida species(56.3%),filamentous fungi(23.4%),and Candida albicans(20.3%).Notably,A.baumannii infections correlated with 76%in-hospital mortality,filamentous fungi with 60%,and S.aureus with 53.8%.Conclusion During ECMO support,patients exhibit a significantly higher positivity rate in sputum specimens compared to other sample types.Patients receiving ECMO are critically ill with compromised immune function,frequently presenting with polymicrobial co-infections.关键词
体外膜氧合/静脉-动脉体外膜氧合/病原菌/院内感染Key words
Extracorporeal membrane oxygenation/Veno-arterial extracorporeal membrane oxygenation/Pathogenic bacteria/Nosocomial infection引用本文复制引用
陈武,刘刚,王靖,王建,王添隆,滕媛,吉冰洋..体外膜氧合支持患者病原菌分布的回顾性研究[J].中国体外循环杂志,2025,23(2):108-112,5.
