中国药科大学学报2025，Vol.56Issue(2)：207-215,9.DOI:10.11665/j.issn.1000-5048.2024091301
汉黄芩素对Aβ1-42和D-半乳糖诱导的小鼠学习记忆损害的改善作用
Wogonin ameliorates Aβ1-42 and D-galactose-induced learning and memory impairment in mice
摘要
Abstract
To investigate the effects of Wogonin(WO)on learning and memory impairment,Aβ1-42 was injected intracerebroventricularly to induced a mouse learning and memory impairment model,and D-galactose was injected intraperitoneally to induced a mouse acute aging model.Mice were administered WO(75,150,or 300 mg/kg)by oral gavage for 28 consecutive days.Cognitive function was assessed using the Morris water maze(MWM),novel object recognition(NOR),and open field tests(OFT).In the Aβ1-42 model,WO treatment(150 and 300 mg/kg)significantly improved the recognition index in the NOR test,while the 150 mg/kg group showed increased target quadrant preference in the MWM test.No changes in the total distance traveled in OFT.In the D-galactose aging model,the 150 mg/kg WO group exhibited increased platform crossings in the MWM test,and all WO doses(75,150,and 300 mg/kg)enhanced target quadrant preference,with no alterations in spontaneous movement.Western blot analysis revealed that WO significantly attenuated hippocampal apoptosis in both models.These findings suggest that WO ameliorates learning and memory impairment associated with Alzheimer's disease and aging.关键词
汉黄芩素/Aβ1-42/D-半乳糖/记忆损害/细胞凋亡Key words
wogonin/Aβ1-42/D-galactose/memory impairment/apoptosis分类
药学引用本文复制引用
章琪露,聂睿哲,魏立彬,郭青龙,唐苏苏..汉黄芩素对Aβ1-42和D-半乳糖诱导的小鼠学习记忆损害的改善作用[J].中国药科大学学报,2025,56(2):207-215,9.基金项目
山东省中央引导地方科技发展资金项目(YDZX2023082) （YDZX2023082）
泰山产业领军人才工程 （）
枣庄英才集聚工程基金项目:山东省枣庄英才计划(2021年,产业创新类) （2021年,产业创新类）
泰山产业创新领军人才 （）
山东省技术创新引导计划(中央引导地方科技发展资金)项目(YDZX2023082) This study was supported by Shandong Central Government Guiding Local Science and Technology Development Funds Program(YDZX2023082),Taishan Industrial Leadership Talent Program,Zaozhuang Talent Aggregation Project Fund:Shandong Zaozhuang Talent Program(2021,Industrial Innovation Category),Taishan Industrial Innovation Leading Talent,and Shandong Technological Innovation Guiding Program(Central Government Guiding Local Science and Technology Development Funds)(YDZX2023082) （中央引导地方科技发展资金）
