中国药科大学学报2025，Vol.56Issue(2)：236-243,8.DOI:10.11665/j.issn.1000-5048.2024122301
新型含铝疫苗佐剂的研究进展
Research progress of new aluminum-containing vaccine adjuvants
摘要
Abstract
Aluminum adjuvants are widely used in the field of vaccines due to their ability to induce efficient and long-lasting immune responses and good safety profile.With the development of immunology,the requirements for adjuvants have gradually increased,and traditional aluminum adjuvants can no longer meet all the needs of application.The development of novel aluminum adjuvants has become a hot research topic in order to achieve good immunity-enhancing effects and induce specific types and strengths of immune responses.This review briefly introduces the mechanism of action and safety of aluminum adjuvants,with focus on the research progress of novel aluminum adjuvants in recent years,mainly including nano-aluminum adjuvants and composite aluminum adjuvants(aluminum adjuvants compounded with immunity-stimulating molecules or delivery carriers),and a prospect of their future research direction,aiming to provide some reference for the further development and clinical application of aluminum adjuvants.关键词
疫苗/铝佐剂/纳米铝佐剂/复合铝佐剂/免疫反应Key words
vaccine/aluminum adjuvant/nano-aluminum adjuvant/composite aluminum adjuvant/immune response分类
医药卫生引用本文复制引用
任红梅,熊晔蓉,荀校莹,姜雷,涂家生..新型含铝疫苗佐剂的研究进展[J].中国药科大学学报,2025,56(2):236-243,8.基金项目
This study was supported by the National Natural Science Foundation of China(No.32271456) 国家自然科学基金项目(No.32271456) （No.32271456）
