中国药科大学学报2025，Vol.56Issue(2)：264-270,7.DOI:10.11665/j.issn.1000-5048.2024110401
甘露醇的药物晶体学研究进展
Progress in pharmaceutical crystallographic study of mannitol
摘要
Abstract
As a pharmaceutical excipient with low caloric value,low hygroscopicity,and high stability,mannitol is widely used in various dosage forms,such as solid,lyophilized and inhalation preparations,etc.It has different crystal structures(α,β and δ)and cocrystal,and the changes in the crystal structure will affect formulation properties of pharmaceutical formulations.This paper reviews structural features,physicochemical properties,and preparation methods of mannitol polymorphs and cocrystal formation,with emphasis on polymorphic transformation pathways,monitoring methods and the effect of polymorphic transformation on properties and application in pharmaceutical formulations,including tabletability,disintegration and dissolution properties.By systematically summarizing the crystallographic study of mannitol,this study attempts to provide new ideas for the development of novel pharmaceutical excipients and applications in pharmaceutical formulations.关键词
甘露醇/多晶型/共晶/多晶型转变/药用辅料Key words
mannitol/polymorph/cocrystal/polymorphic transform/pharmaceutical excipient分类
医药卫生引用本文复制引用
刘慧娜,张珂,缪妍,魏元锋,高缘..甘露醇的药物晶体学研究进展[J].中国药科大学学报,2025,56(2):264-270,7.基金项目
This study was supported by the National Natural Science Foundation of China(No.82104401,No.82274217,No.82204636,No.82373824) 国家自然科学基金项目(No.82104401,No.82274217,No.82204636,No.82373824) （No.82104401,No.82274217,No.82204636,No.82373824）
