中国药房2025，Vol.36Issue(8)：961-965,5.DOI:10.6039/j.issn.1001-0408.2025.08.12
肠内免疫微生态营养联合ω-3鱼油脂肪乳用于肝细胞癌切除术后的临床观察
Clinical observation of enteral immune microecological nutrition combined with ω-3 fish oil fat emulsion for postoperative hepatocellular carcinoma resection
摘要
Abstract
OBJECTIVE To study the effects of enteral immune microecological nutrition combined with ω-3 fish oil fat emulsion on postoperative recovery,immune function,liver function and inflammation level in patients with hepatocellular carcinoma resection,as well as the safety of the medication.METHODS A total of 106 patients with hepatocellular carcinoma admitted to our Hospital from June 2020 to December 2023 were selected and divided into control group and study group according to the random number table method,with 53 cases in each group.After undergoing hepatocellular carcinoma resection,control group was given Intacted protein enteral nutrition solution+Enhanced enteral immune microecological nutrition,and the study group was given ω-3 fish oil fat emulsion injection based on the control group.The clinical indicators(postoperative exhaust time,defecation time,postoperative ambulation,and hospital stay),liver function indicators[alanine transaminase(ALT),lactate dehydrogenase(LDH),aspartate transaminase(AST)],immune function indexes(CD3+,CD4+,CD8+,CD4+/CD8+),inflammatory factor indexes[tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-6,IL-8],and indicators of intestinal mucosal barrier[D-lactic acid,intestinal fatty acid binding protein(I-FABP)]were compared between 2 groups,and the occurrence of ADR was recorded.RESULTS Compared with the control group,the postoperative exhaust time,postoperative defecation time,and hospital stay of the study group were shortened significantly,and postoperative ambulation increased significantly(P＜0.05).After treatment,ALT,LDH,AST,CD8+,inflammatory factors,D-lactic acid and I-FABP of 2 groups were significantly lower than before treatment,and the study group was significantly lower than the control group(P＜0.05);CD4+,CD3+,and CD4+/CD8+of two groups were significantly higher than before treatment,and the study group was significantly higher than the control group(P＜0.05).There was no significant difference in the incidence of ADR between 2 groups(P＞0.05).CONCLUSIONS Enteral immune microecological nutrition combined with ω-3 fish oil fat emulsion injection can shorten the recovery time of patients after hepatocellular carcinoma resection,improve immune function,reduce inflammatory response,and improve liver function with good safety.关键词
肠内免疫微生态营养/ω-3鱼油脂肪乳/肝细胞癌/免疫功能/炎症因子Key words
enteral immune microecological nutrition/ω-3 fish oil fat emulsion/hepatocellular carcinoma/immune function/inflammatory factors分类
医药卫生引用本文复制引用
张明,颜华英,徐东平,王晶晶,张立成,齐玉梅..肠内免疫微生态营养联合ω-3鱼油脂肪乳用于肝细胞癌切除术后的临床观察[J].中国药房,2025,36(8):961-965,5.基金项目
天津市科学技术项目(No.2020BKY162) （No.2020BKY162）
