中国药房2025，Vol.36Issue(8)：981-985,5.DOI:10.6039/j.issn.1001-0408.2025.08.16
1例热紫链霉菌肺炎诊治过程及文献复习
Diagnosis and treatment process of a case of Streptomyces thermoviolaceus pneumonia and literature review
摘要
Abstract
OBJECTIVE To report the diagnosis and treatment process of 1 case of Streptomyces thermoviolaceus pneumonia,and provide reference for the diagnosis and treatment of this type of infection by combining literature on Streptomyces pneumonia.METHODS A case study was conducted on a patient with S.thermoviolaceus pneumonia treated at the First Affiliated Hospital of Army Medical University.Additionally,a systematic literature review of Streptomyces pneumonia cases was performed.RESULTS The patient with S.thermoviolaceus presented with left lung consolidation and mass-like opacity.Initial diagnosis via matrix-assisted laser desorption/ionization time-of-flight mass spectrometry failed,but 16S rRNA gene amplification and sequencing confirmed S.thermoviolaceus as the causative pathogen.Six-month therapy with Amoxicillin capsules(1 g orally,three times daily)resulted in near-complete lesion resolution.The literature analysis of Streptomyces pneumonia revealed that 13 patients with Streptomyces pneumonia were included(including the patient reported in the article),age range of 18-77 years,more males(8 cases),and mostly suffering from underlying diseases.In terms of clinical symptoms,all enrolled cases exhibited cough,and some cases were accompanied by variable dyspnea.Imaging findings included that there was no characteristic predilection site for Streptomyces pneumonia lesions,and CT images commonly showed lung consolidation and bilateral nodules.Definitive diagnosis relied on 16S rRNA sequencing.Treatment regimens included tetracyclines,β-lactam drugs combined with enzyme inhibitors,ceftriaxone,aminoglycosides,macrolides,or carbapenems,administered for prolonged duration(6 months).Follow-up indicated a good prognosis,and only one mortality occurred.CONCLUSIONS 16S rRNA gene sequencing should be prioritized for diagnosing S.pneumonia.Effective antimicrobial options include tetracyclines,β-lactam drugs combined with enzyme inhibitors,ceftriaxone,aminoglycosides,macrolides,and carbapenems.Prolonged therapy correlates with favorable prognosis.关键词
链霉菌肺炎/热紫链霉菌/16S rRNA/肺部感染Key words
Streptomyces pneumonia/Streptomyces thermoviolaceus/16s rRNA/pulmonary infection分类
临床医学引用本文复制引用
刘攀,戴晓天,刘婷婷,江灏,梁岚..1例热紫链霉菌肺炎诊治过程及文献复习[J].中国药房,2025,36(8):981-985,5.基金项目
重庆市卫生健康委医学科研项目(No.2023-WSJK055) （No.2023-WSJK055）
