摘要
Abstract
Objective To explore the effect of Aspergillus oryzae pancrease combined with probiotics on functional diarrhea and its effect on recurrence rate.Methods A total of 82 patients with functional diarrhea admitted to the First Hospital of Dandong City from January 2020 to January 2023 were randomly divided into probiotic group and combination group,with 41 cases each.Probiotics group was given live clostridium butyricum tablets alone,and the combined group was added rice aspergillus pancreatic enzyme tablets on the basis of control group.The clinical efficacy,the frequency of defecation and related symptom scores,the relevant serum biochemical indexes of gastrin-17(G-17),pepsinogen Ⅱ(PG-Ⅱ),pepsinogen Ⅰ(PG-Ⅰ),the occurrence of adverse reactions during medication and the recurrence of 1-year follow-up were compared between the two groups.Results The total clinical effective rate of the combined group was higher than that of the probiotic group(P＜0.05).There were no significant differences in defecation frequency,stool trait score and abdominal distension score between the two groups before treatment(P＞0.05).After treatment,the frequency of defecation,stool trait score and abdominal distension score were all decreased(P＜0.05),and the combined group was lower than the probiotic group(P＜0.05).There were no significant differences in serum G-17,PG-Ⅱand PG-Ⅰ levels between two groups before treatment(P＞0.05).After treatment,the serum levels of G-17,PG-Ⅱ and PG-Ⅰ in 2 groups were increased(P＜0.05),and those in combination group were higher than those in probiotic group(P＜0.05).No significant adverse reactions occurred in the two groups during treatment,and no cases were lost to follow-up through 1-year follow-up.The recurrence rate of functional diarrhea was 4.88%in the combined group and 31.71%in the probiotic group during follow-up,with statistical significance between the two groups(P＜0.05).Conclusion The combination of Monascus trypsin and probiotics has a significant effect on the treatment of functional diarrhea,and compared with simple probiotic treatment,it can reduce the frequency of bowel movements,improve stool characteristics and abdominal distension,increase relevant serum biochemical indicators,reduce long-term recurrence rate,and has high safety.关键词
米曲菌胰酶/益生菌/功能性腹泻/复发率/胃蛋白酶原/胃泌素-17Key words
Rice yeast trypsin/Probiotics/Functional diarrhea/Recurrence rate/Pepsinogen/Gastrin-17分类
临床医学
