摘要
Abstract
Objective To explore the safety and cost-effectiveness of different proton pump inhibitors quadruple therapy in the treatment of peptic ulcers.Methods A total of 100 patients with peptic ulcer admitted to Fuxin Mine General Hospital of Liaojian Group from January 2021 to January 2024 were selected and divided into 1,2,3 and 4 groups according to random number table method,with 25 cases in each group.All patients were treated with proton pump inhibitor+clarithromycin+amoxicillin+colloidal pectin bismuth.Preprazole was used as proton pump inhibitor in group 1,pantoprazole in group 2,rabeprazole in group 3,and Lansoprazole in group 4.The clinical efficacy,expression levels of α-defencin,transforming growth faction-β1(TGF-β1)and gastrin before and after treatment,incidence of adverse reactions and cost-effectiveness of the 4 groups were compared.Results There was no significant difference in the total effective rate among the 4 groups(P＞0.05).After treatment,the level of α-defandrin in 4 groups was higher than before treatment(P＜0.05),and the levels of TGF-β1 and gastrin were lower than before treatment(P＜0.05),but there were no significant differences in the levels of α-defandrin,TGF-β1 and gastrin in 4 groups before and after treatment(P＞0.05).There was no significant difference in the incidence of adverse reactions among the 4 groups(P＞0.05).4 Groups C/E from low to high are 3,1,2,and 4 groups.Conclusion Tetrad therapy with proton pump inhibitors has a significant effect on the treatment of peptic ulcer,and can improve the expression level of gastrointestinal hormone in patients,and there is no significant difference in the total effective rate,safety and impact on gastrointestinal hormone levels of the four different proton pump inhibitors.However,the use of rapeprazole is more cost-effective and can be used as the first choice for the treatment of peptic ulcer.关键词
质子泵抑制剂/四联疗法/消化性溃疡/安全性/成本-效益/胃肠激素Key words
Proton pump inhibitors/Quadruple therapy/Peptic ulcer/Security/Cost effectiveness/Gastrointestinal hormones分类
医药卫生
