中国医学创新2025，Vol.22Issue(10)：19-23,5.DOI:10.3969/j.issn.1674-4985.2025.10.005
胸椎旁神经阻滞联合全身麻醉对肺癌根治术老年患者认知功能的影响
The Impact of Thoracic Paravertebral Block Combined with General Anesthesia on Cognitive Function in Elderly Patients Undergoing Radical Resection of Lung Cancer
摘要
Abstract
Objective:To investigate the effect of thoracic paravertebral block combined with general anesthesia on cognitive function in elderly patients undergoing radical resection of lung cancer.Method:Prospectively enrolled 80 elderly patients who underwent radical resection of lung cancer at Xuzhou Municipal Hospital Affiliated to Xuzhou Medical University from January 2022 to January 2024.Patients were randomly divided into combined anesthesia group(thoracic paravertebral block combined with general anesthesia)and simple general anesthesia group(simple general anesthesia),with 40 cases in each group.Plasma matrix metalloproteinase-9(MMP-9),lipoprotein-phospholipase A2(Lp-PLA2),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels were compared between the two groups,and mini-mental state examination(MMSE)and event-related potential p300 were used to evaluate cognitive function in both groups.Result:The levels of MMP-9,Lp-PLA2,IL-6 and TNF-α in both groups at 1 and 7 d after surgery were higher than those at 1 d before surgery,and those of the combined anesthesia group were lower than those in the general anesthesia group.Compared with the simple general anesthesia group,the P300 latency was shorter and the P300 amplitude and MMSE score were higher in the combined anesthesia group at 7 d after surgery.Conclusion:Thoracic paravertebral block can effectively reduce neuroinflammatory response and improve cognitive function in elderly patients after radical resection of lung cancer under general anesthesia.关键词
胸椎旁神经阻滞/肺癌手术/术后认知功能障碍/神经保护/炎症因子Key words
Thoracic paravertebral block/Radical resection of lung cancer/Postoperative cognitive dysfunction/Neuroprotection/Inflammatory factors引用本文复制引用
杨丽,安晓雷,张进..胸椎旁神经阻滞联合全身麻醉对肺癌根治术老年患者认知功能的影响[J].中国医学创新,2025,22(10):19-23,5.基金项目
2023年江苏省卫生健康委科研课题(Ym2023012) （Ym2023012）
2023年度徐州市医药卫生面上项目(KC23160) （KC23160）
徐州市重点研发项目-医药卫生面上项目(KC22175) （KC22175）
徐州医科大学附属医院发展基金资助项目(XYFM202236) （XYFM202236）
