中国医学创新2025，Vol.22Issue(10)：183-188,6.DOI:10.3969/j.issn.1674-4985.2025.10.043
允许性高碳酸血症对腹腔镜手术老年患者术后认知功能的影响及研究进展
Impact and Research Progress of Permissible Hypercapnia on Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Laparoscopic Surgery
摘要
Abstract
In current medical practice,with the extensive application of laparoscopic technology in elderly patients,postoperative cognitive dysfunction(POCD)has become a key problem affecting the rehabilitation and quality of life of elderly patients.Permissible hypercapnia(PHC)is an acceptable respiratory acidosis resulting from the use of low tidal volume protective ventilation strategies.Clinical studies have shown that the application of PHC in laparoscopic surgery can improve postoperative cognitive function in elderly patients through various mechanisms.It is important to note that although PHC has shown potential benefits in multiple studies,several key issues regarding its use in elderly patients remain unclear:first,the mechanism of overall effect of PHC on the physiological status of elderly patients has not been fully elucidated;secondly,the specific role of PHC strategy in postoperative pain management and its potential impact on postoperative cognitive function still need to be further verified;finally,there is still a lack of clear clinical consensus on key parameters such as allowable limits and safe limits for CO2 during PHC therapy.In this paper,we reviewed the influence of PHC ventilation strategy on elderly patients undergoing laparoscopic surgery and the related mechanisms.关键词
允许性高碳酸血症/术后认知功能障碍/腹腔镜手术/老年患者Key words
Permissible hypercapnia/Postoperative cognitive dysfunction/Laparoscopic surgery/Elderly patients引用本文复制引用
闵雪,吕志坚,李孔兵,贾钰婕,王冬梅..允许性高碳酸血症对腹腔镜手术老年患者术后认知功能的影响及研究进展[J].中国医学创新,2025,22(10):183-188,6.基金项目
青海大学附属医院(临床医学院)科学创新基金项目(FYXC-2024-06) （临床医学院）
