中国医学创新2025，Vol.22Issue(11)：21-25,5.DOI:10.3969/j.issn.1674-4985.2025.11.005
活血复元胶囊联合地舒单抗治疗绝经后骨质疏松性肋骨骨折的临床效果
Clinical Effect of Huoxue Fuyuan Capsules Combined with Denosumab in the Treatment of Postmenopausal Osteoporotic Rib Fractures
摘要
Abstract
Objective:To investigate the effect of Huoxue Fuyuan Capsules combined with Denosumab in the treatment of postmenopausal patients with osteoporotic rib fractures.Method:A total of 180 postmenopausal patients with osteoporotic rib fractures admitted to Nanchang Hongdu Hospital of TCM from January 2022 to May 2023 were randomly divided into three groups,with 60 patients in each group.The control group 1 was treated with Huoxue Fuyuan Capsules,the control group 2 was treated with Denosumab,and the observation group was treated with Huoxue Fuyuan Capsules combined with Denosumab.All three groups were treated for one year.The pain degree,clinical indicators,bone mineral density,four items of osteoporosis and imaging examination were compared among the three groups.Result:The visual analog scale(VAS)scores of the observation group after 6,9,12,and 15 days of treatment were lower than those of control group 1 and control group 2,the differences were statistically significant(P<0.05).The observation group had shorter pain duration and hospitalization time compared to control group 1 and control group 2,and the disappearance time of swelling and pain was earlier than that of control group 1 and control group 2,with statistically significant differences(P<0.05).After 6 and 12 months of treatment,the BMD of the femoral neck and lumbar spine in all three groups increased,and those of the observation group were higher than those of the control group 1 and control group 2,with statistically significant differences(P<0.05).After 6 and 12 months of treatment,the levels of β collagen specific sequence(β-CTX),type Ⅰ collagen N-terminal extended peptide(PⅠNP),and osteocalcin(OST)in all three groups decreased compared to before treatment,and those of the observation group were lower than those of control group 1 and control group 2,with statistically significant differences(P<0.05).After 3,6,9 and 12 months of treatment,the fracture healing rates of the observation group were higher than those of control group 1 and control group 2,and the incidence of new fractures were lower than those of control group 1 and control group 2,with statistically significant differences(P<0.05).Conclusion:The treatment of postmenopausal osteoporotic rib fractures with Huoxue Fuyuan Capsules combined with Denosumab can alleviate pain,improve bone density and osteoporosis,and promote fracture healing.关键词
绝经/骨质疏松/肋骨骨折/活血复元胶囊/地舒单抗Key words
Menopause/Osteoporosis/Rib fracture/Huoxue Fuyuan Capsules/Denosumab引用本文复制引用
杨盼盼,胡俊,张斌,叶小青,谈荣珍,朱莹,袁忠..活血复元胶囊联合地舒单抗治疗绝经后骨质疏松性肋骨骨折的临床效果[J].中国医学创新,2025,22(11):21-25,5.基金项目
江西省中医药管理局科技计划项目(2023B0687) （2023B0687）
