摘要
Abstract
Objective:To investigate the clinical effect of Yixinshu Tablets combined with Rosuvastatin in the treatment of stable angina pectoris(SAP)complicated with hyperlipidemia.Method:A total of 153 patients with SAP complicated with hyperlipidemia admitted to Shijingshan Teaching Hospital of Capital Medical University(Beijing Shijingshan Hospital)from January 2022 to October 2024 were selected and divided into the combination group,control group 1 and control group 2 according to random number table,with 51 cases in each group.The combination group was treated with Yixinshu Tablets combined with Rosuvastatin,the control group 1 was treated with Rosuvastatin,and the control group 2 was treated with Yixinshu Tablets,all of which were treated for 8 weeks.The angina pectoris symptoms effect,lipid-lowering effect,angina pectoris attack related indexes serological indexes,hemorheological indexes and safety of the three groups were compared.Result:The total effective rate of angina pectoris symptoms and lipid-lowering in combination group were 92.16%and 94.12%,respectively,which were significantly higher than 76.47%and 80.39%in control group 1 and 74.51%and 76.47%in control group 2,the differences were statistically significant(P<0.05).After treatment,the frequency of angina pectoris in combination group was less than that in control group 1 and control group 2,the duration time was shorter than that in control group 1 and control group 2,and the visual analogue scale(VAS)score was lower than that in control group 1 and control group 2,the differences were statistically significant(P<0.05).Total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),triglycerides(TG),matrix metalloproteinase-9(MMP-9),soluble CD40 ligand(sCD40L),interleukin-6(IL-6)levels and plasma viscosity(PV),fibrinogen(FIB),erythrocyte aggregation index(EAI),erythrocyte deformability index(EDI)in combination group after treatment were significantly lower than those of control group 1 and control group 2,the high density lipoprotein cholesterol(HDL-C)level was significantly higher than that of control group 1 and control group 2,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:Yixinshu Tablets combined with Rosuvastatin has a definite overall effect in the treatment of SAP complicated with hyperlipidemia,which can effectively improve the attack of angina pectoris and abnormal lipid metabolism in patients,further improve hemorrheology,reduce the levels of serum inflammatory factors,and has a good therapeutic safety.关键词
益心舒片/瑞舒伐他汀/稳定型心绞痛/高脂血症/血液流变学/炎症反应Key words
Yixinshu Tablets/Rosuvastatin/Stable angina pectoris/Hyperlipidemia/Hemorheology/Inflammatory reaction
