摘要
Abstract
Objective:To explore the efficacy and safety of Ginkgolide Injection combined with Citicoline Sodium Tablets in the treatment of cerebral infarction convalescence period.Method:A total of 108 cerebral infarction convalescence period patients admitted to Fengcheng People's Hospital from January 2022 to January 2024 were selected.They were divided into control group and observation group by random number table method,with 54 cases in each group.The control group was treated with Citicoline Sodium Tablets,and the observation group was treated with Ginkgolide Injection combined with Citicoline Sodium Tablets.The clinical efficacy,neurological function,functional rehabilitation status,serum inflammatory mediators,oxidative stress indexes and incidence of adverse reactions were compared between the two groups.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the national institutes of health stroke scale(NIHSS),modified Rankin scale(mRS)scores,C reactive protein(CRP),interleukin-6(IL-6)and interleukin-8(IL-8)in the observation group were lower than those in the control group,superoxide dismutase(SOD)was higher than that in control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The treatment of Ginkgolide Injection combined with Citicoline Sodium Tablets can promote the recovery of nerve function,reduce the oxidative stress response,regulate the level of inflammatory mediators,and improve the functional rehabilitation of patients in the convalescent period of cerebral infarction,with good safety.关键词
脑梗死恢复期/银杏内酯注射液/胞磷胆碱钠片/神经功能/安全性Key words
Cerebral infarction convalescence period/Ginkgolide Injection/Citicoline Sodium Tablets/Neurological function/Safety
