摘要
Abstract
Objective:To explore the effect of Vancomycin combined with Meropenem in the treatment of postoperative intracranial infection after recurrent cerebral gliomas and its effect on inflammation and cerebrospinal fluid indexes.Method:A total of 80 patients with postoperative intracranial infection after recurrent cerebral gliomas were selected from Beijing North Asia Orthopaedic Hospital from November 2019 to November 2023.According to the random number table method,the patients were divided into two groups,with 40 cases in each group.The control group was treated with Meropenem,and the observation group was treated with Vancomycin on the basis of the control group.The total effective rate,incidence of adverse reactions,onset time,inflammatory response indexes[serum nuclear factor-κB(NF-κB),interleukin-6(IL-6),interleukin-8(IL-8)and white blood cell count(WBC)]and cerebrospinal fluid related indexes[high mobility group protein B-1(HMGB-1),heparin-binding protein(HBP),neuron-specific enolase(NSE)and S100 calcium binding protein B(S100B)]before and after treatment between the two groups were compared.Result:The total effective rate of treatment in the observation group was significantly higher than that in the control group,and the onset time was earlier than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there were no statistical significance in the inflammatory response indexes and cerebrospinal fluid related indexes between the two groups(P>0.05);after 3 and 7 days of treatment,the inflammatory response indexes and cerebrospinal fluid related indexes between the two groups were significantly lower than those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Vancomycin combined with Meropenem is effective in the treatment of intracranial infection after recurrent cerebal glioma,and can effectively control and improve the inflammatory response and the expression of cerebrospinal fluid indicators.关键词
万古霉素/复发脑胶质瘤/术后颅内感染/炎症反应/脑脊液指标Key words
Vancomycin/Recurrent cerebral gliomas/Postoperative intracranial infection/Inflammatory reactions/Cerebrospinal fluid indexes
