中国医学创新2025，Vol.22Issue(11)：144-148,5.DOI:10.3969/j.issn.1674-4985.2025.11.032
PaRftZLfx方案在难治性肺结核中的应用效果评价
Evaluation of the Application Effect of PaRftZLfx Regimen in Refractory Pulmonary Tuberculosis
摘要
Abstract
Objective:To explore the value of PaRftZLfx regimen in the treatment of refractory pulmonary tuberculosis.Method:A total of 80 patients with refractory pulmonary tuberculosis were selected,all of whom were admitted to the Department of Lung Disease of Yangzhou Third People's Hospital from February 2022 to October 2023.They were randomly divided into two groups according to the random number method.The control group(40 cases)received LfxEPAS chemotherapy regimen,while the observation group(40 cases)received PaRftZLfx treatment.The clinical efficacy after 3 months of treatment,sputum conversion rate after 2,4,and 6 months of treatment,cavity closure after 6 months of treatment,incidence of adverse reactions within 3 months,and changes in immune function after 3 months of treatment were compared.Result:The total effective rate,sputum conversion rate,and cavity closure in the observation group were all better than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Compared with before treatment,CD3+,CD4+,CD4+/CD8+in both groups increased significantly after 3 months of treatment,while CD8+decreased significantly,the observation group were superior to the control group,the differences were statistically significant(P<0.05).Conclusion:Choosing PaRftZLfx in the treatment of refractory pulmonary tuberculosis can improve cavity closure,sputum conversion rate,ensure treatment effectiveness and safety,and enhance immune function.关键词
利福喷丁/难治性肺结核/空洞闭合/痰菌转阴Key words
Rifapentine/Refractory pulmonary tuberculosis/Cavity closure/Sputum conversion引用本文复制引用
黄自强,朱晶,张设,吴俊杰..PaRftZLfx方案在难治性肺结核中的应用效果评价[J].中国医学创新,2025,22(11):144-148,5.基金项目
扬州市科技计划项目(YZ2021074) （YZ2021074）
